Polymorphisms in the CTLA-4 Gene and Rheumatoid Arthritis Susceptibility: a Meta-analysis

Overview

Journal J Clin Immunol

Publisher Springer

Specialty Allergy & Immunology

Date 2012 Feb 23

PMID 22354566

Citations 12

Authors

Xiaobo Li

Cong Zhang

Jie Zhang

Yonggang Zhang

Zhangjun Wu

Lian Yang

Zhangpeng Xiang

Zhanzhong Qi

Xin Zhang

Xingqiong Xiao

Affiliations

Soon will be listed here.

Abstract

Introduction: The +49A/G polymorphism and CT60 polymorphism in the CTLA-4 gene have been extensively examined for the association with rheumatoid arthritis (RA); however, results of different studies have been inconclusive. The aim of this study is to comprehensively evaluate the genetic risks of +49A/G and CT60 polymorphisms in the CTLA-4 gene for RA.

Methods: A meta-analysis was carried out to analyze the association of +49A/G and CT60 polymorphisms with RA risk.

Results: A total of 30 case-control studies in 20 articles were included in this meta-analysis. The results indicated that the variant G allele carriers (GG + GA) of +49A/G polymorphism had an 18% increased risk of RA when compared with the homozygote AA (odds ratio (OR) = 1.18, 95% confidence interval (CI): 1.04-1.34 for GG + AG vs. AA). In addition, the variant CT60 A allele carriers of CT60 polymorphism had a 14% decreased risk of RA when compared with the homozygote GG (OR = 0.86, 95%CI = 0.78-0.95 for AA + AG vs. GG). In the subgroup analysis by ethnicity, significant elevated RA risks were associated with +49G allele carriers in Asians, but not in Europeans. However, for CT60 polymorphism, significant decreased RA risks were associated with CT60 A allele carriers in Europeans, but not in Asians.

Conclusions: This meta-analysis suggested that the +49A/G and CT60 polymorphisms in the CTLA-4 gene may be risk factors for RA.

Citing Articles

Association between gene polymorphism and risk of rheumatoid arthritis: a meta-analysis.

Zhou C, Gao S, Yuan X, Shu Z, Li S, Sun X Aging (Albany NY). 2021; 13(15):19397-19414.

PMID: 34339393 PMC: 8386564. DOI: 10.18632/aging.203349.

The Association Between , and Gene Polymorphisms and Rheumatoid Arthritis: An Original Study and Meta-Analysis.

Liu W, Yang Z, Chen Y, Yang H, Wan X, Zhou X Front Med (Lausanne). 2021; 8:598076.

PMID: 33604347 PMC: 7884472. DOI: 10.3389/fmed.2021.598076.

Steiner S, Becker S, Hartwig J, Sotzny F, Lorenz S, Bauer S Front Immunol. 2020; 11:578.

PMID: 32328064 PMC: 7161310. DOI: 10.3389/fimmu.2020.00578.

Immune checkpoint inhibitor-induced inflammatory arthritis as a model of autoimmune arthritis.

Cappelli L, Thomas M, Bingham 3rd C, Shah A, Darrah E Immunol Rev. 2020; 294(1):106-123.

PMID: 31930524 PMC: 7047521. DOI: 10.1111/imr.12832.

The synergic effects of CTLA-4/Foxp3-related genotypes and chromosomal aberrations on the risk of recurrent spontaneous abortion among a Chinese Han population.

Fan Q, Zhang J, Cui Y, Wang C, Xie Y, Wang Q J Hum Genet. 2018; 63(5):579-587.

PMID: 29476189 PMC: 5915418. DOI: 10.1038/s10038-018-0414-2.

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