Chemoprevention of Pancreatic Cancer-one Step Closer

Overview

Journal Langenbecks Arch Surg

Specialty General Surgery

Date 2012 Feb 22

PMID 22350613

Citations 5

Authors

Volker Fendrich

Affiliations

Soon will be listed here.

Abstract

Background: Since for pancreatic cancer the mortality rate approaches the incidence rate with only 1-4% of all patients surviving 5 years, it would be would be of great value to provide chemopreventive treatment for high-risk individuals.

Discussion: The preclinical study of pancreatic intraepithelial neoplasia (PanINs) has recently been made possible by the generation of genetically modified animal models, which recapitulate human PanINs and invasive pancreatic cancer on a genetic and histomorphologic level. Very recently, several groups have reported first evidence of chemoprevention of pancreatic cancer.

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