Vitamin D Supplementation in Infants with Chronic Congestive Heart Failure

Overview

Journal Pediatr Cardiol

Specialties Cardiology & Vascular Diseases
Pediatrics

Date 2012 Feb 22

PMID 22349668

Citations 33

Authors

Soad A Shedeed

Affiliations

Soon will be listed here.

Abstract

Increased circulating proinflammatory cytokines may contribute to the pathogenesis of congestive heart failure (CHF). In vitro studies have suggested that vitamin D suppresses proinflammatory cytokines and increases anti-inflammatory cytokines. The aim of this work was to evaluate the effect of vitamin D supplementation on renin-angiotensin system cytokines as well as different clinical, biochemical, and echocardiographic variables in infants with chronic CHF. This was a double-blind, placebo-controlled intervention study and included 80 infants with CHF. The intervention consisted of either giving Vitamin D(3) oral drops (group I) or placebo oral drops (group II). In both study groups, baseline 25-hydroxyvitamin D [25(OH)D] concentrations were below the lower end of the reference range. After 12 weeks of intervention, vitamin D supplementation for group I infants caused significant improvement of HF score, left-ventricular (LV) end-diastolic diameter, LV end-systolic diameter, LV ejection fraction%, and myocardial performance index together with markedly increased serum 25(OH)D and interleukin (IL)-10 and decreased PTH, IL-6, and TNF-α compared with the placebo group; these differences were statistically significant (p < 0.001). Vitamin D supplementation has great benefits as an anti-inflammatory agent in infants with CHF. It helps acceleration of the clinical improvement and cytokine profile balance.

Citing Articles

Vitamin D on Cardiac Function in Heart Failure: A Systematic Review and Meta-Analysis of 10 RCTs.

Chen X, Zhao W, Zhao Y, Ma J, Bu H, Zhao Y Rev Cardiovasc Med. 2024; 24(11):325.

PMID: 39076451 PMC: 11272839. DOI: 10.31083/j.rcm2411325.

Effect of vitamin D on myocardial remodeling and inflammatory status in children with congenital heart disease.

Gokalp S, Tunaoglu F, Canbeyli F, Terlemez S, Atasayan V, Aral L Turk J Med Sci. 2023; 52(6):1900-1905.

PMID: 36945996 PMC: 10390163. DOI: 10.55730/1300-0144.5537.

Is Hypovitaminosis D a Risk Factor for Heart Failure?.

Hagau A, Puscas A, Toganel R, Muntean I Life (Basel). 2023; 13(2).

PMID: 36836729 PMC: 9967471. DOI: 10.3390/life13020372.

Association Between the Circulating Level of 25-Hydroxyvitamin D and Clinical Results After Cardiac Surgery: A Meta-Analysis and Systematic Review.

Zhang Y, Li J, Qiu Y, Gong X, He Y, Yue P Front Cardiovasc Med. 2021; 8:734504.

PMID: 34869636 PMC: 8634434. DOI: 10.3389/fcvm.2021.734504.

Vitamin D and Cardiovascular Disease: An Updated Narrative Review.

Zittermann A, Trummer C, Theiler-Schwetz V, Lerchbaum E, Marz W, Pilz S Int J Mol Sci. 2021; 22(6).

PMID: 33809311 PMC: 7998446. DOI: 10.3390/ijms22062896.

References

Rostand S, Drueke T . Parathyroid hormone, vitamin D, and cardiovascular disease in chronic renal failure. Kidney Int. 1999; 56(2):383-92. DOI: 10.1046/j.1523-1755.1999.00575.x. View

Stoddard M, Pearson A, Kern M, Ratcliff J, Mrosek D, Labovitz A . Influence of alteration in preload on the pattern of left ventricular diastolic filling as assessed by Doppler echocardiography in humans. Circulation. 1989; 79(6):1226-36. DOI: 10.1161/01.cir.79.6.1226. View

Wagner C, Greer F . Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008; 122(5):1142-52. DOI: 10.1542/peds.2008-1862. View

Rauchhaus M, Doehner W, Francis D, Davos C, Kemp M, Liebenthal C . Plasma cytokine parameters and mortality in patients with chronic heart failure. Circulation. 2000; 102(25):3060-7. DOI: 10.1161/01.cir.102.25.3060. View

Zhu Y, Mahon B, Froicu M, Cantorna M . Calcium and 1 alpha,25-dihydroxyvitamin D3 target the TNF-alpha pathway to suppress experimental inflammatory bowel disease. Eur J Immunol. 2004; 35(1):217-24. DOI: 10.1002/eji.200425491. View

Lee J, OKeefe J, Bell D, Hensrud D, Holick M . Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor?. J Am Coll Cardiol. 2008; 52(24):1949-56. DOI: 10.1016/j.jacc.2008.08.050. View

Tomar M, Radhakrishnan S, Shrivastava S . Myocardial dysfunction due to hypocalcemia. Indian Pediatr. 2010; 47(9):781-3. DOI: 10.1007/s13312-010-0117-z. View

De Vries J . Immunosuppressive and anti-inflammatory properties of interleukin 10. Ann Med. 1995; 27(5):537-41. DOI: 10.3109/07853899509002465. View

Tishkoff D, Nibbelink K, Holmberg K, Dandu L, Simpson R . Functional vitamin D receptor (VDR) in the t-tubules of cardiac myocytes: VDR knockout cardiomyocyte contractility. Endocrinology. 2007; 149(2):558-64. PMC: 2219302. DOI: 10.1210/en.2007-0805. View

10.

Pacher R, Frey B, Kos T, Woloszczuk W, Stanek B . Circulating tumor necrosis factor-alpha levels in chronic heart failure: relation to its soluble receptor II, interleukin-6, and neurohumoral variables. J Heart Lung Transplant. 1998; 17(4):356-62. View

11.

Weber K, Simpson R, Carbone L . Vitamin D and calcium dyshomoeostasis-associated heart failure. Heart. 2008; 94(5):540-1. DOI: 10.1136/hrt.2007.126359. View

12.

Ross R, Bollinger R, Pinsky W . Grading the severity of congestive heart failure in infants. Pediatr Cardiol. 1992; 13(2):72-5. DOI: 10.1007/BF00798207. View

13.

Bodyak N, Ayus J, Achinger S, Shivalingappa V, Ke Q, Chen Y . Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals. Proc Natl Acad Sci U S A. 2007; 104(43):16810-5. PMC: 2040477. DOI: 10.1073/pnas.0611202104. View

14.

Canning M, Grotenhuis K, de Wit H, Ruwhof C, Drexhage H . 1-alpha,25-Dihydroxyvitamin D3 (1,25(OH)(2)D(3)) hampers the maturation of fully active immature dendritic cells from monocytes. Eur J Endocrinol. 2001; 145(3):351-7. DOI: 10.1530/eje.0.1450351. View

15.

Zittermann A, Schleithoff S, Tenderich G, Berthold H, Korfer R, Stehle P . Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?. J Am Coll Cardiol. 2003; 41(1):105-12. DOI: 10.1016/s0735-1097(02)02624-4. View

16.

Kim D, Sabour S, Sagar U, Adams S, Whellan D . Prevalence of hypovitaminosis D in cardiovascular diseases (from the National Health and Nutrition Examination Survey 2001 to 2004). Am J Cardiol. 2008; 102(11):1540-4. DOI: 10.1016/j.amjcard.2008.06.067. View

17.

Schleithoff S, Zittermann A, Tenderich G, Berthold H, Stehle P, Koerfer R . Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2006; 83(4):754-9. DOI: 10.1093/ajcn/83.4.754. View