Identification of the Porosome Complex in the Hair Cell

Overview

Journal Cell Biol Int Rep (2010)

Specialty Cell Biology

Date 2012 Feb 21

PMID 22348194

Citations 10

Authors

Dennis G Drescher

Won Jin Cho

Marian J Drescher

Affiliations

Soon will be listed here.

Abstract

Porosomes are proposed to be the universal secretory machinery of the cell plasma membrane, where membrane-bound secretory vesicles transiently dock and fuse to expel their contents to the extracellular space during cell secretion. In neurons, porosomes are manifested as cup-shaped lipoprotein structures in the presynaptic membrane, 12-17 nm in diameter and possessing a central plug. Hair cells of hearing and balance secrete transmitter from synaptic vesicles in sensory signal transduction, but it has not previously been demonstrated that these mechanosensory cells possess porosome structures that could participate in the secretory process. In the current study, we provide, for the first time, evidence obtained using transmission electron microscopy that porosome structures indeed exist in the hair cell, suggesting a mechanism of hair-cell transmitter secretion markedly different from that of the exocytotic process currently proposed.

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