Adaptogens Stimulate Neuropeptide Y and Hsp72 Expression and Release in Neuroglia Cells

Overview

Journal Front Neurosci

Date 2012 Feb 21

PMID 22347152

Citations 15

Authors

Alexander Panossian

Georg Wikman

Punit Kaur

Alexzander Asea

Affiliations

Soon will be listed here.

Abstract

The beneficial stress-protective effect of adaptogens is related to the regulation of homeostasis via mechanisms of action associated with the hypothalamic-pituitary-adrenal axis and the regulation of key mediators of the stress response, such as molecular chaperones, stress-activated c-Jun N-terminal protein kinase, forkhead box O transcription factor, cortisol, and nitric oxide (NO). However, it still remains unclear what the primary upstream targets are in response to stimulation by adaptogens. The present study addresses this gap in our knowledge and suggests that an important target for adaptogen mediated stress-protective effector functions is the stress hormone neuropeptide Y (NPY). We demonstrated that ADAPT-232, a fixed combination of adaptogens Eleutherococcus senticosus root extract, Schisandra chinensis berry extract, Rhodiola rosea root extract SHR-5, and its active constituent salidroside, stimulated the expression of NPY and 72 kDa heat shock protein (Hsp72) in isolated human neuroglia cells. The central role of NPY was validated in experiments in which pre-treatment of human neuroglia cells with NPY-siRNA and HSF1-siRNA resulted in the significant suppression of ADAPT-232-induced NPY and Hsp72 release. Taken together our studies suggest that the stimulation and release of the stress hormones, NPY and Hsp72, into systemic circulation is an innate defense response against mild stressors (ADAPT-232), which increase tolerance and adaptation to stress.

Citing Articles

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Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases.

Panossian A, Efferth T, Shikov A, Pozharitskaya O, Kuchta K, Mukherjee P Med Res Rev. 2020; 41(1):630-703.

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The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory Infections.

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Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled, Two-Armed Cross-Over Study.

Dimpfel W, Schombert L, Keplinger-Dimpfel I, Panossian A Pharmaceuticals (Basel). 2020; 13(3).

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Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea.

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PMID: 32178272 PMC: 7139475. DOI: 10.3390/antiox9030234.

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