Paucity of HIV DNA Methylation in Latently Infected, Resting CD4+ T Cells from Infected Individuals Receiving Antiretroviral Therapy

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2012 Feb 21

PMID 22345448

Citations 61

Authors

Jana Blazkova

Danielle Murray

J Shawn Justement

Emily K Funk

Amy K Nelson

Susan Moir

Tae-Wook Chun

Anthony S Fauci

Affiliations

Soon will be listed here.

Abstract

Maintenance of HIV latency in vitro has been linked to methylation of HIV DNA. However, examinations of the degree of methylation of HIV DNA in the latently infected, resting CD4(+) T cells of infected individuals receiving antiretroviral therapy have been limited. Here, we show that methylation of the HIV 5' long terminal repeat (LTR) in the latent viral reservoir of HIV-infected aviremic individuals receiving therapy is rare, suggesting that other mechanisms are likely involved in the persistence of viral latency.

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