Convection Enhanced Delivery of Macromolecules for Brain Tumors

Overview

Journal Curr Drug Discov Technol

Publisher Bentham Science Publishers

Date 2012 Feb 21

PMID 22339074

Citations 20

Authors

Ankit I Mehta

Bryan D Choi

Divya Ajay

Raghu Raghavan

Martin Brady

Allan H Friedman

Ira Pastan

Darell D Bigner

John H Sampson

Affiliations

Soon will be listed here.

Abstract

The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer therapeutic compounds. The efficacy of CED is dependent on the distribution of the therapeutic agent to the targeted region. Here we present a review of convection enhanced delivery of macromolecules, emphasizing the role of tracers in enabling effective delivery anddiscuss current challenges in the field.

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