Access to Skipped Polyene Macrolides Through Ring-closing Metathesis: Total Synthesis of the RNA Polymerase Inhibitor Ripostatin B

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2012 Feb 17

PMID 22337614

Citations 9

Authors

Philipp Winter

Wolf Hiller

Mathias Christmann

Affiliations

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Abstract

Rip-Roaring! A convergent total synthesis of antibiotic ripostatin B was developed. A key step in the synthesis is a metathesis reaction allowing for a ring closure to the labile doubly skipped triene macrolide.

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