Platelet Gel in Oral and Maxillofacial Surgery: a Single-centre Experience

Overview

Journal Blood Transfus

Specialty Hematology

Date 2012 Feb 17

PMID 22337267

Citations 5

Authors

Andrea Dominijanni

Maria Giulia Cristofaro

Adalgisa Brescia

Mario Giudice

Affiliations

Soon will be listed here.

Abstract

Background: Platelet gel is a blood product intended for non-transfusion, therapeutic purposes; it is produced by combining platelet concentrate with cryoprecipitate. Platelet gel stimulates tissue growth and is a key player in tissue regeneration. As an allogeneic product, platelet gel is obtained from the blood of a common type O blood donor, with a platelet count >200×10(3)/μL. Most of the beneficial effects of this product are due to the numerous growth factors (PDGF, TGF-β, IGF-1 and IGF-2, EGF, VEGF and FGF) contained in the alpha-granules of platelets. The aim of this study was to confirm that platelet gel is a valuable aid for the surgical repair of alveolar bone loss.

Materials And Methods: Our study was carried out on 87 patients with inflammatory or dysembryoplastic osteolytic lesions >2 cm in diameter in jaw bones. For most patients the platelet gel was collected into a 450 mL bag and kept frozen at -40 °C until, whereas for a small group of patients the gel was prepared and activated in the sterile field of the operating theatre.

Results: All of our patients reported a decrease in painful symptoms immediately after surgery. Follow-up showed considerable acceleration of the healing processes in soft tissues and faster bone regeneration.

Conclusion: Multicentre studies are needed in order to standardise the methods for producing platelet gel and the clinical use of this product. Furthermore, for research purposes in vitro studies are needed to increase knowledge on the functional network and platelet growth factors and also to investigate the biochemical and molecular mechanisms involved.

Citing Articles

Effects and mechanism of platelet-rich plasma on military drill injury: a review.

Xu P, Xuan M, Cheng B Mil Med Res. 2020; 7(1):56.

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Efficacy of Autologous Platelet-Rich Gel for Diabetic Foot Wound Healing: A Meta-Analysis of 15 Randomized Controlled Trials.

Ding H, Fu X, Miao W, Mao X, Zhan M, Chen H Adv Wound Care (New Rochelle). 2019; 8(5):195-207.

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Evaluation of autologous platelet rich plasma for cardiac surgery: outcome analysis of 2000 patients.

Patel A, Selzman C, Kumpati G, McKellar S, Bull D J Cardiothorac Surg. 2016; 11(1):62.

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Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction.

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Platelet-rich plasma inside the sternotomy wound reduces the incidence of sternal wound infections.

Serraino G, Dominijanni A, Jiritano F, Rossi M, Cuda A, Caroleo S Int Wound J. 2013; 12(3):260-4.

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