Interferon-γ-producing Immature Myeloid Cells Confer Protection Against Severe Invasive Group A Streptococcus Infections

Overview

Journal Nat Commun

Specialty Biology

Date 2012 Feb 16

PMID 22334081

Citations 17

Authors

Takayuki Matsumura

Manabu Ato

Tadayoshi Ikebe

Makoto Ohnishi

Haruo Watanabe

Kazuo Kobayashi

Affiliations

Soon will be listed here.

Abstract

Cytokine-activated neutrophils are known to be essential for protection against group A Streptococcus infections. However, during severe invasive group A Streptococcus infections that are accompanied by neutropenia, it remains unclear which factors are protective against such infections, and which cell population is the source of them. Here we show that mice infected with severe invasive group A Streptococcus isolates, but not with non-invasive group A Streptococcus isolates, exhibit high concentrations of plasma interferon-γ during the early stage of infection. Interferon-γ is necessary to protect mice, and is produced by a novel population of granulocyte-macrophage colony-stimulating factor-dependent immature myeloid cells with ring-shaped nuclei. These interferon-γ-producing immature myeloid cells express monocyte and granulocyte markers, and also produce nitric oxide. The adoptive transfer of interferon-γ-producing immature myeloid cells ameliorates infection in wild-type and interferon-γ-deficient mice. Our results indicate that interferon-γ-producing immature myeloid cells have a protective role during the early stage of severe invasive group A Streptococcus infections.

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