The Role of TRADD in Death Receptor Signaling

Overview

Journal Cell Cycle

Specialty Cell Biology

Date 2012 Feb 16

PMID 22333735

Citations 62

Authors

Yelena L Pobezinskaya

Zhenggang Liu

Affiliations

Soon will be listed here.

Abstract

TRADD (TNFR1-associated death domain protein) was initially identified as an adaptor molecule that transduces the signal downstream of the TNFR1 (tumor necrosis factor receptor 1). TNFR1 belongs to the so-called death receptor (DR) family of receptors that depending on the context can induce either apoptosis or proliferation, as well as NF-κB and MAP kinase activation. The receptors of this group contain death domain (DD) that is necessary for the induction of apoptosis. This review summarizes the recent advances in the field of DR signaling and in particular the role of TRADD.

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