The Effects of Temperature and Relative Humidity on the Viability of the SARS Coronavirus

Overview

Journal Adv Virol

Publisher Wiley

Specialty Microbiology

Date 2012 Feb 8

PMID 22312351

Citations 441

Authors

K H Chan

J S Malik Peiris

S Y Lam

L L M Poon

K Y Yuen

W H Seto

Affiliations

Soon will be listed here.

Abstract

The main route of transmission of SARS CoV infection is presumed to be respiratory droplets. However the virus is also detectable in other body fluids and excreta. The stability of the virus at different temperatures and relative humidity on smooth surfaces were studied. The dried virus on smooth surfaces retained its viability for over 5 days at temperatures of 22-25°C and relative humidity of 40-50%, that is, typical air-conditioned environments. However, virus viability was rapidly lost (>3 log(10)) at higher temperatures and higher relative humidity (e.g., 38°C, and relative humidity of >95%). The better stability of SARS coronavirus at low temperature and low humidity environment may facilitate its transmission in community in subtropical area (such as Hong Kong) during the spring and in air-conditioned environments. It may also explain why some Asian countries in tropical area (such as Malaysia, Indonesia or Thailand) with high temperature and high relative humidity environment did not have major community outbreaks of SARS.

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References

Pirtle E, Beran G . Virus survival in the environment. Rev Sci Tech. 1991; 10(3):733-48. DOI: 10.20506/rst.10.3.570. View

Ksiazek T, Erdman D, Goldsmith C, Zaki S, Peret T, Emery S . A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003; 348(20):1953-66. DOI: 10.1056/NEJMoa030781. View

Peiris J, Chu C, Cheng V, Chan K, Hung I, Poon L . Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet. 2003; 361(9371):1767-72. PMC: 7112410. DOI: 10.1016/s0140-6736(03)13412-5. View

Drosten C, Gunther S, Preiser W, van der Werf S, Brodt H, Becker S . Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med. 2003; 348(20):1967-76. DOI: 10.1056/NEJMoa030747. View

Cai Q, Lu J, Xu Q, Guo Q, Xu D, Sun Q . Influence of meteorological factors and air pollution on the outbreak of severe acute respiratory syndrome. Public Health. 2007; 121(4):258-65. PMC: 7118752. DOI: 10.1016/j.puhe.2006.09.023. View

Lin K, Fong D, Zhu B, Karlberg J . Environmental factors on the SARS epidemic: air temperature, passage of time and multiplicative effect of hospital infection. Epidemiol Infect. 2006; 134(2):223-30. PMC: 2870397. DOI: 10.1017/S0950268805005054. View

Brady M, Evans J, Cuartas J . Survival and disinfection of parainfluenza viruses on environmental surfaces. Am J Infect Control. 1990; 18(1):18-23. DOI: 10.1016/0196-6553(90)90206-8. View

Booth T, Kournikakis B, Bastien N, Ho J, Kobasa D, Stadnyk L . Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units. J Infect Dis. 2005; 191(9):1472-7. PMC: 7202477. DOI: 10.1086/429634. View

Yu I, Li Y, Wong T, Tam W, Chan A, Lee J . Evidence of airborne transmission of the severe acute respiratory syndrome virus. N Engl J Med. 2004; 350(17):1731-9. DOI: 10.1056/NEJMoa032867. View

10.

Rabenau H, Cinatl J, Morgenstern B, Bauer G, Preiser W, Doerr H . Stability and inactivation of SARS coronavirus. Med Microbiol Immunol. 2004; 194(1-2):1-6. PMC: 7086689. DOI: 10.1007/s00430-004-0219-0. View

11.

Yuan J, Yun H, Lan W, Wang W, Sullivan S, Jia S . A climatologic investigation of the SARS-CoV outbreak in Beijing, China. Am J Infect Control. 2006; 34(4):234-6. PMC: 7115332. DOI: 10.1016/j.ajic.2005.12.006. View

12.

Casanova L, Jeon S, Rutala W, Weber D, Sobsey M . Effects of air temperature and relative humidity on coronavirus survival on surfaces. Appl Environ Microbiol. 2010; 76(9):2712-7. PMC: 2863430. DOI: 10.1128/AEM.02291-09. View

13.

Chan V, Chan K, Chen Y, Poon L, Cheung A, Zheng B . Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. Nat Genet. 2005; 38(1):38-46. PMC: 7097088. DOI: 10.1038/ng1698. View

14.

Donnelly C, Ghani A, Leung G, Hedley A, Fraser C, Riley S . Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong. Lancet. 2003; 361(9371):1761-6. PMC: 7112380. DOI: 10.1016/S0140-6736(03)13410-1. View

15.

Sizun J, Yu M, Talbot P . Survival of human coronaviruses 229E and OC43 in suspension and after drying onsurfaces: a possible source ofhospital-acquired infections. J Hosp Infect. 2000; 46(1):55-60. PMC: 7134510. DOI: 10.1053/jhin.2000.0795. View

16.

Tan J, Mu L, Huang J, Yu S, Chen B, Yin J . An initial investigation of the association between the SARS outbreak and weather: with the view of the environmental temperature and its variation. J Epidemiol Community Health. 2005; 59(3):186-92. PMC: 1733040. DOI: 10.1136/jech.2004.020180. View

17.

Seto W, Tsang D, Yung R, Ching T, Ng T, Ho M . Effectiveness of precautions against droplets and contact in prevention of nosocomial transmission of severe acute respiratory syndrome (SARS). Lancet. 2003; 361(9368):1519-20. PMC: 7112437. DOI: 10.1016/s0140-6736(03)13168-6. View

18.

Darnell M, Subbarao K, Feinstone S, Taylor D . Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV. J Virol Methods. 2004; 121(1):85-91. PMC: 7112912. DOI: 10.1016/j.jviromet.2004.06.006. View

19.

Lai M, Cheng P, Lim W . Survival of severe acute respiratory syndrome coronavirus. Clin Infect Dis. 2005; 41(7):e67-71. PMC: 7107832. DOI: 10.1086/433186. View

20.

Hall C, DOUGLAS Jr R, Geiman J . Possible transmission by fomites of respiratory syncytial virus. J Infect Dis. 1980; 141(1):98-102. DOI: 10.1093/infdis/141.1.98. View