Effect of Byrsonima Crassa and Phenolic Constituents on Helicobacter Pylori-induced Neutrophils Oxidative Burst

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2012 Feb 8

PMID 22312243

Citations 5

Authors

Cibele Bonacorsi

Maria Stella G Raddi

Luiz Marcos da Fonseca

Miriam Sannomiya

Wagner Vilegas

Affiliations

Soon will be listed here.

Abstract

Byrsonima crassa Niedenzu (Malpighiaceae) is used in Brazilian folk medicine for the treatment of diseases related mainly to gastric ulcers. In a previous study, our group described the gastric protective effect of the methanolic extract from the leaves of B. crassa. The present study was carried out to investigate the effects of methanolic extract and its phenolic compounds on the respiratory burst of neutrophils stimulated by H. pylori using a luminol-based chemiluminescence assay as well as their anti-H. pylori activity. The suppressive activity on oxidative burst of H. pylori-stimulated neutrophils was in the order of methyl gallate > (+)-catechin > methanol extract > quercetin 3-O-α-l-arabinopyranoside > quercetin 3-O-β-d-galactopyranoside > amentoflavone. Methyl gallate, compound that induced the highest suppressive activity with IC(50) value of 3.4 μg/mL, did not show anti-H. pylori activity. B. crassa could be considered as a potential source of natural antioxidant in gastric ulcers by attenuating the effects on the damage to gastric mucosa caused by neutrophil generated reactive oxygen species, even when H. pylori displays its evasion mechanisms.

Citing Articles

Antioxidant, Anti-Inflammatory, Anti-Diabetic, and Pro-Osteogenic Activities of Polyphenols for the Treatment of Two Different Chronic Diseases: Type 2 Diabetes Mellitus and Osteoporosis.

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The effects and mechanisms of natural products on eradication.

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Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid.

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Efficacy of quercetin derivatives in prevention of ulcerative colitis in rats.

Sotnikova R, Nosalova V, Navarova J Interdiscip Toxicol. 2013; 6(1):9-12.

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Comparison of Brazilian Plants Used to Treat Gastritis on the Oxidative Burst of Helicobacter pylori-Stimulated Neutrophil.

Bonacorsi C, da Fonseca L, Raddi M, Kitagawa R, Vilegas W Evid Based Complement Alternat Med. 2013; 2013:851621.

PMID: 23970939 PMC: 3732590. DOI: 10.1155/2013/851621.

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