Ventromedial Prefrontal-subcortical Systems and the Generation of Affective Meaning

Overview

Journal Trends Cogn Sci

Date 2012 Feb 8

PMID 22310704

Citations 400

Authors

Mathieu Roy

Daphna Shohamy

Tor D Wager

Affiliations

Soon will be listed here.

Abstract

The ventromedial prefrontal cortex (vmPFC) comprises a set of interconnected regions that integrate information from affective sensory and social cues, long-term memory, and representations of the 'self'. Alhough the vmPFC is implicated in a variety of seemingly disparate processes, these processes are organized around a common theme. The vmPFC is not necessary for affective responses per se, but is critical when affective responses are shaped by conceptual information about specific outcomes. The vmPFC thus functions as a hub that links concepts with brainstem systems capable of coordinating organism-wide emotional behavior, a process we describe in terms of the generation of affective meaning, and which could explain the common role played by the vmPFC in a range of experimental paradigms.

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References

Amodio D, Frith C . Meeting of minds: the medial frontal cortex and social cognition. Nat Rev Neurosci. 2006; 7(4):268-77. DOI: 10.1038/nrn1884. View

Lindquist K, Wager T, Kober H, Bliss-Moreau E, Barrett L . The brain basis of emotion: a meta-analytic review. Behav Brain Sci. 2012; 35(3):121-43. PMC: 4329228. DOI: 10.1017/S0140525X11000446. View

Barrett L . Solving the emotion paradox: categorization and the experience of emotion. Pers Soc Psychol Rev. 2006; 10(1):20-46. DOI: 10.1207/s15327957pspr1001_2. View

Coghill R, Sang C, Maisog J, Iadarola M . Pain intensity processing within the human brain: a bilateral, distributed mechanism. J Neurophysiol. 1999; 82(4):1934-43. DOI: 10.1152/jn.1999.82.4.1934. View

Noonan M, Walton M, Behrens T, Sallet J, Buckley M, Rushworth M . Separate value comparison and learning mechanisms in macaque medial and lateral orbitofrontal cortex. Proc Natl Acad Sci U S A. 2010; 107(47):20547-52. PMC: 2996698. DOI: 10.1073/pnas.1012246107. View

McClure S, Laibson D, Loewenstein G, Cohen J . Separate neural systems value immediate and delayed monetary rewards. Science. 2004; 306(5695):503-7. DOI: 10.1126/science.1100907. View

Fellows L, Farah M . Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm. Brain. 2003; 126(Pt 8):1830-7. DOI: 10.1093/brain/awg180. View

van Reekum C, Johnstone T, Urry H, Thurow M, Schaefer H, Alexander A . Gaze fixations predict brain activation during the voluntary regulation of picture-induced negative affect. Neuroimage. 2007; 36(3):1041-55. DOI: 10.1016/j.neuroimage.2007.03.052. View

Urry H, van Reekum C, Johnstone T, Davidson R . Individual differences in some (but not all) medial prefrontal regions reflect cognitive demand while regulating unpleasant emotion. Neuroimage. 2009; 47(3):852-63. PMC: 2766667. DOI: 10.1016/j.neuroimage.2009.05.069. View

10.

Wager T, van Ast V, Hughes B, Davidson M, Lindquist M, Ochsner K . Brain mediators of cardiovascular responses to social threat, part II: Prefrontal-subcortical pathways and relationship with anxiety. Neuroimage. 2009; 47(3):836-51. PMC: 4169880. DOI: 10.1016/j.neuroimage.2009.05.044. View

11.

Price J . Definition of the orbital cortex in relation to specific connections with limbic and visceral structures and other cortical regions. Ann N Y Acad Sci. 2007; 1121:54-71. DOI: 10.1196/annals.1401.008. View

12.

MONTGOMERY G, Kirsch I . Classical conditioning and the placebo effect. Pain. 1997; 72(1-2):107-13. DOI: 10.1016/s0304-3959(97)00016-x. View

13.

Schiller D, Levy I, Niv Y, LeDoux J, Phelps E . From fear to safety and back: reversal of fear in the human brain. J Neurosci. 2008; 28(45):11517-25. PMC: 3844784. DOI: 10.1523/JNEUROSCI.2265-08.2008. View

14.

Blakemore S . Imaging brain development: the adolescent brain. Neuroimage. 2011; 61(2):397-406. DOI: 10.1016/j.neuroimage.2011.11.080. View

15.

Ochsner K, Knierim K, Ludlow D, Hanelin J, Ramachandran T, Glover G . Reflecting upon feelings: an fMRI study of neural systems supporting the attribution of emotion to self and other. J Cogn Neurosci. 2005; 16(10):1746-72. DOI: 10.1162/0898929042947829. View

16.

Critchley H, Nagai Y, Gray M, Mathias C . Dissecting axes of autonomic control in humans: Insights from neuroimaging. Auton Neurosci. 2010; 161(1-2):34-42. DOI: 10.1016/j.autneu.2010.09.005. View

17.

Plassmann H, ODoherty J, Shiv B, Rangel A . Marketing actions can modulate neural representations of experienced pleasantness. Proc Natl Acad Sci U S A. 2008; 105(3):1050-4. PMC: 2242704. DOI: 10.1073/pnas.0706929105. View

18.

Picard N, Strick P . Imaging the premotor areas. Curr Opin Neurobiol. 2001; 11(6):663-72. DOI: 10.1016/s0959-4388(01)00266-5. View

19.

Schoenbaum G, Takahashi Y, Liu T, McDannald M . Does the orbitofrontal cortex signal value?. Ann N Y Acad Sci. 2011; 1239:87-99. PMC: 3530400. DOI: 10.1111/j.1749-6632.2011.06210.x. View

20.

Binder J, Desai R, Graves W, Conant L . Where is the semantic system? A critical review and meta-analysis of 120 functional neuroimaging studies. Cereb Cortex. 2009; 19(12):2767-96. PMC: 2774390. DOI: 10.1093/cercor/bhp055. View