Industrial Toxicants and Parkinson's Disease

Overview

Journal Neurotoxicology

Specialties Environmental Health
Neurology
Toxicology

Date 2012 Feb 8

PMID 22309908

Citations 60

Authors

W Michael Caudle

Thomas S Guillot

Carlos R Lazo

Gary W Miller

Affiliations

Soon will be listed here.

Abstract

The exposure of the human population to environmental contaminants is recognized as a significant contributing factor for the development of Parkinson's disease (PD) and other forms of parkinsonism. While pesticides have repeatedly been identified as risk factors for PD, these compounds represent only a subset of environmental toxicants that we are exposed to on a regular basis. Thus, non-pesticide contaminants, such as metals, solvents, and other organohalogen compounds have also been implicated in the clinical and pathological manifestations of these movement disorders and it is these non-pesticide compounds that are the subject of this review. As toxic exposures to these classes of compounds can result in a spectrum of PD or PD-related disorders, it is imperative to appreciate shared clinico-pathological characteristics or mechanisms of action of these compounds in order to further delineate the resultant disorders as well as identify improved preventive strategies or therapeutic interventions.

Citing Articles

Developmental origins of Parkinson's disease risk: perinatal exposure to the organochlorine pesticide dieldrin leads to sex-specific DNA modifications in critical neurodevelopmental pathways in the mouse midbrain.

Kochmanski J, Virani M, Kuhn N, Boyd S, Becker K, Adams M Toxicol Sci. 2024; 201(2):263-281.

PMID: 38995845 PMC: 11424889. DOI: 10.1093/toxsci/kfae091.

Neurotoxicology of dopamine: Victim or assailant?.

Bucher M, Dicent J, Hospital C, Miller G Neurotoxicology. 2024; 103:175-188.

PMID: 38857676 PMC: 11694735. DOI: 10.1016/j.neuro.2024.06.001.

Kochmanski J, Virani M, Kuhn N, Boyd S, Becker K, Adams M bioRxiv. 2024; .

PMID: 38746441 PMC: 11092502. DOI: 10.1101/2024.04.26.590998.

Association Study Between Kynurenine 3-Monooxygenase (KMO) Gene and Parkinson's Disease Patients.

Babu H, Elangovan A, Iyer M, Kirola L, Muthusamy S, Jeeth P Mol Neurobiol. 2023; 61(7):3867-3881.

PMID: 38040995 DOI: 10.1007/s12035-023-03815-9.

Mitigation of the Deleterious Effect of Heavy Metals on the Conformational Stability of Ubiquitin through Osmoprotectants.

Alazoumi K, Sharma P, Islam A, Farooqi H Cell Biochem Biophys. 2023; 82(1):193-202.

PMID: 37843791 DOI: 10.1007/s12013-023-01188-3.

References

Bourdineaud J, Fujimura M, Laclau M, Sawada M, Yasutake A . Deleterious effects in mice of fish-associated methylmercury contained in a diet mimicking the Western populations' average fish consumption. Environ Int. 2010; 37(2):303-13. DOI: 10.1016/j.envint.2010.09.003. View

Fechter L, Johnson D, Lynch R . The relationship of particle size to olfactory nerve uptake of a non-soluble form of manganese into brain. Neurotoxicology. 2002; 23(2):177-83. DOI: 10.1016/s0161-813x(02)00013-x. View

Seegal R, Brosch K, Bush B, Ritz M, Shain W . Effects of Aroclor 1254 on dopamine and norepinephrine concentrations in pheochromocytoma (PC-12) cells. Neurotoxicology. 1989; 10(4):757-64. View

Reddy N, Sudini M, Lewis L . Delayed neurological sequelae from ethylene glycol, diethylene glycol and methanol poisonings. Clin Toxicol (Phila). 2011; 48(10):967-73. DOI: 10.3109/15563650.2010.532803. View

Normandin L, Beaupre L, Salehi F, St -Pierre A, Kennedy G, Mergler D . Manganese distribution in the brain and neurobehavioral changes following inhalation exposure of rats to three chemical forms of manganese. Neurotoxicology. 2004; 25(3):433-41. DOI: 10.1016/j.neuro.2003.10.001. View

McLean D, Jacobs H, Mielke B . Methanol poisoning: a clinical and pathological study. Ann Neurol. 1980; 8(2):161-7. DOI: 10.1002/ana.410080206. View

Reistad T, Fonnum F, Mariussen E . Neurotoxicity of the pentabrominated diphenyl ether mixture, DE-71, and hexabromocyclododecane (HBCD) in rat cerebellar granule cells in vitro. Arch Toxicol. 2006; 80(11):785-96. DOI: 10.1007/s00204-006-0099-8. View

Fahn S . Description of Parkinson's disease as a clinical syndrome. Ann N Y Acad Sci. 2003; 991:1-14. DOI: 10.1111/j.1749-6632.2003.tb07458.x. View

Hudnell H . Effects from environmental Mn exposures: a review of the evidence from non-occupational exposure studies. Neurotoxicology. 1999; 20(2-3):379-97. View

10.

Friedman A, Arosio P, Finazzi D, Koziorowski D, Galazka-Friedman J . Ferritin as an important player in neurodegeneration. Parkinsonism Relat Disord. 2011; 17(6):423-30. DOI: 10.1016/j.parkreldis.2011.03.016. View

11.

Albin R, Young A, Penney J . The functional anatomy of basal ganglia disorders. Trends Neurosci. 1989; 12(10):366-75. DOI: 10.1016/0166-2236(89)90074-x. View

12.

Lee D, Notter S, Thiruchelvam M, Dever D, Fitzpatrick R, Kostyniak P . Subchronic polychlorinated biphenyl (Aroclor 1254) exposure produces oxidative damage and neuronal death of ventral midbrain dopaminergic systems. Toxicol Sci. 2011; 125(2):496-508. PMC: 3262858. DOI: 10.1093/toxsci/kfr313. View

13.

Huang C, Chu N, Lu C, Wang J, Tsai J, Tzeng J . Chronic manganese intoxication. Arch Neurol. 1989; 46(10):1104-6. DOI: 10.1001/archneur.1989.00520460090018. View

14.

Sofic E, Riederer P, Heinsen H, Beckmann H, Reynolds G, Hebenstreit G . Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain. J Neural Transm. 1988; 74(3):199-205. DOI: 10.1007/BF01244786. View

15.

Yin Z, Jiang H, Syversen T, Rocha J, Farina M, Aschner M . The methylmercury-L-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter. J Neurochem. 2008; 107(4):1083-90. PMC: 2581650. DOI: 10.1111/j.1471-4159.2008.05683.x. View

16.

Seegal R, Pappas B, Park G . Neurochemical effects of consumption of Great Lakes salmon by rats. Regul Toxicol Pharmacol. 1998; 27(1 Pt 2):S68-75. DOI: 10.1006/rtph.1997.1192. View

17.

Borisova T, Krisanova N, Sivko R, Kasatkina L, Borysov A, Griffin S . Presynaptic malfunction: the neurotoxic effects of cadmium and lead on the proton gradient of synaptic vesicles and glutamate transport. Neurochem Int. 2011; 59(2):272-9. DOI: 10.1016/j.neuint.2011.05.014. View

18.

Bemis J, Seegal R . PCB-induced inhibition of the vesicular monoamine transporter predicts reductions in synaptosomal dopamine content. Toxicol Sci. 2004; 80(2):288-95. DOI: 10.1093/toxsci/kfh153. View

19.

Taylor T, Caudle W, Shepherd K, Noorian A, Jackson C, Iuvone P . Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacity. J Neurosci. 2009; 29(25):8103-13. PMC: 2813143. DOI: 10.1523/JNEUROSCI.1495-09.2009. View

20.

Kamrin M, Fischer L, Suk W, Fouts J, Pellizzari E, Thornton K . Assessment of human exposure to chemicals from Superfund sites. Environ Health Perspect. 1994; 102 Suppl 1:221-8. PMC: 1566893. DOI: 10.1289/ehp.94102s1221. View