Emerging Roles of the Neuronal Nucleolus

Overview

Journal Trends Neurosci

Specialty Neurology

Date 2012 Feb 7

PMID 22305768

Citations 68

Authors

Michal Hetman

Maciej Pietrzak

Affiliations

Soon will be listed here.

Abstract

Although, the nucleolus has been observed for almost 200 years in neurons, studies that directly address the neuronal roles of this subnuclear structure have appeared only recently. The aim of this review is to discuss recent progress and identify some critical questions that remain to be answered. As expected for the cellular center of ribosome biogenesis, the nucleolus is essential for the growth of developing neurons, including neurite morphogenesis and long-term maintenance of mature neurons. In addition, the nucleolus contributes to neuronal stress responses, including the regulation of apoptosis. Hence, disrupted neurodevelopment or neurodegeneration are among the likely consequences of nucleolar dysfunction. Conversely, the presence of active nucleoli may determine the potential for neurorepair.

Citing Articles

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Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy.

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Single-cell laser emitting cytometry for label-free nucleolus fingerprinting.

Fang G, Qiao Z, Huang L, Zhu H, Xie J, Zhou T Nat Commun. 2024; 15(1):7332.

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