Worldwide Variations in EGFR Somatic Mutations: a Challenge for Personalized Medicine

Overview

Journal Diagn Pathol

Publisher Biomed Central

Specialty Pathology

Date 2012 Feb 2

PMID 22293080

Citations 6

Authors

Pierre-Jean Lamy

William Jacot

Affiliations

Soon will be listed here.

Abstract

Two studies recently reported around 10% of EGFR activating mutations in triple negative breast cancers from Asian patients. However, we did not find any EGFR activating mutation in a series of 229 breast tumor samples from European patients. Like in lung cancer, the EGFR mutation profiles seem to be related to the ethnical origin of patients. This is an important point that should be considered when developing anti-EGFR therapies.

Citing Articles

Somatic mutational landscape across Indian breast cancer cases by whole exome sequencing.

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Mutations of the Epidermal Growth Factor Receptor Gene in Triple-Negative Breast Cancer.

Kim A, Jang M, Lee S, Bae Y J Breast Cancer. 2017; 20(2):150-159.

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Whole-Exome Sequencing Identifies Novel Somatic Mutations in Chinese Breast Cancer Patients.

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The epidermal growth factor receptor (EGFR / HER-1) gatekeeper mutation T790M is present in European patients with early breast cancer.

Bemanian V, Sauer T, Touma J, Lindstedt B, Chen Y, Presterud Odegard H PLoS One. 2015; 10(8):e0134398.

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Immunohistochemical detection of mutations in the epidermal growth factor receptor gene in lung adenocarcinomas using mutation-specific antibodies.

Xiong Y, Bai Y, Leong N, Laughlin T, Rothberg P, Xu H Diagn Pathol. 2013; 8:27.

PMID: 23419122 PMC: 3635899. DOI: 10.1186/1746-1596-8-27.

References

Bhargava R, Gerald W, Li A, Pan Q, Lal P, Ladanyi M . EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations. Mod Pathol. 2005; 18(8):1027-33. DOI: 10.1038/modpathol.3800438. View

Marquez-Garban D, Mah V, Alavi M, Maresh E, Chen H, Bagryanova L . Progesterone and estrogen receptor expression and activity in human non-small cell lung cancer. Steroids. 2011; 76(9):910-20. PMC: 3129425. DOI: 10.1016/j.steroids.2011.04.015. View

Jacot W, Lopez-Crapez E, Thezenas S, Senal R, Fina F, Bibeau F . Lack of EGFR-activating mutations in European patients with triple-negative breast cancer could emphasise geographic and ethnic variations in breast cancer mutation profiles. Breast Cancer Res. 2011; 13(6):R133. PMC: 3326575. DOI: 10.1186/bcr3079. View

Broet P, Dalmasso C, Tan E, Alifano M, Zhang S, Wu J . Genomic profiles specific to patient ethnicity in lung adenocarcinoma. Clin Cancer Res. 2011; 17(11):3542-50. DOI: 10.1158/1078-0432.CCR-10-2185. View

Generali D, Leek R, Fox S, Moore J, Taylor C, Chambers P . EGFR mutations in exons 18-21 in sporadic breast cancer. Ann Oncol. 2007; 18(1):203-205. DOI: 10.1093/annonc/mdl322. View

Fukumoto K, Usami N, Okasaka T, Kawaguchi K, Okagawa T, Suzuki H . Late breast metastasis from resected lung cancer diagnosed by epidermal growth factor receptor gene mutation. Lung Cancer. 2011; 74(2):352-3. DOI: 10.1016/j.lungcan.2011.08.015. View

Reis-Filho J, Milanezi F, Carvalho S, Simpson P, Steele D, Savage K . Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis. Breast Cancer Res. 2005; 7(6):R1028-35. PMC: 1410747. DOI: 10.1186/bcr1341. View

Lv N, Xie X, Ge Q, Lin S, Wang X, Kong Y . Epidermal growth factor receptor in breast carcinoma: association between gene copy number and mutations. Diagn Pathol. 2011; 6:118. PMC: 3248849. DOI: 10.1186/1746-1596-6-118. View

Liu L, Shao X, Gao W, Bai J, Wang R, Huang P . The role of human epidermal growth factor receptor 2 as a prognostic factor in lung cancer: a meta-analysis of published data. J Thorac Oncol. 2010; 5(12):1922-32. DOI: 10.1097/jto.0b013e3181f26266. View

10.

Toyama T, Yamashita H, Kondo N, Okuda K, Takahashi S, Sasaki H . Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers. BMC Cancer. 2008; 8:309. PMC: 2612006. DOI: 10.1186/1471-2407-8-309. View

11.

Teng Y, Tan W, Thike A, Cheok P, Man-Kit Tse G, Wong N . Mutations in the epidermal growth factor receptor (EGFR) gene in triple negative breast cancer: possible implications for targeted therapy. Breast Cancer Res. 2011; 13(2):R35. PMC: 3219198. DOI: 10.1186/bcr2857. View