MTHFR Polymorphisms and Breast Cancer Risk

Overview

Journal Arch Med Sci

Specialty General Medicine

Date 2012 Feb 1

PMID 22291746

Citations 32

Authors

Mojgan Hosseini

Massoud Houshmand

Ahmad Ebrahimi

Affiliations

Soon will be listed here.

Abstract

Introduction: Two functional single nucleotide polymorphisms (SNPs) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, lead to decreased enzyme activity and affect chemosensitivity of tumour cells.

Material And Methods: We evaluated these two common polymorphisms and breast cancer risk association in an Iranian sporadic breast cancer population-based case-control study of 294 breast cancer cases and 306 controls using a PCR-RFLP-based assay.

Results: Analyses of affected and controls show that homozygote genotype MTHFR 677CC has the highest frequency in both groups (28.3% in patients and 25.3% in control group). Genotype MTHFR 677CT and genotype MTHFR 1298AC were found to be statistically significant risk factors in our population (odds ratio: 1.6, 95% CI: 1.019-2.513, p = 0.041; and odds ratio: 2.575, 95% CI: 1.590-4.158, p = 0.001 respectively).

Conclusions: We can conclude based on the results of our study that a significant association between breast cancer and C677T and A1298C polymorphism might exist.

Citing Articles

Metabolic Analysis of Methylenetetrahydrofolate Reductase Single Nucleotide Polymorphisms (MTHFR 677C<T and MTHFR 1298A<C), Serum Folate and Vitamin B12 in Neural Tube Defects.

Hassan M, Raslan M, Tharwat M, Sakhr H, El-Khateeb E, Sakr S Indian J Clin Biochem. 2023; 38(3):305-315.

PMID: 37234187 PMC: 10205924. DOI: 10.1007/s12291-022-01049-5.

Variations in folate prescriptions for patients with the MTHFR genetic polymorphisms: A case series study.

Ledowsky C, Schloss J, Steel A Explor Res Clin Soc Pharm. 2023; 10:100277.

PMID: 37228355 PMC: 10205484. DOI: 10.1016/j.rcsop.2023.100277.

Strong Correlation of MTHFR Gene Polymorphisms with Breast Cancer and its Prognostic Clinical Factors among Egyptian Females.

Omran M, Fotouh B, Shousha W, Ismail A, Ibrahim N, Ramadan S Asian Pac J Cancer Prev. 2021; 22(2):617-626.

PMID: 33639682 PMC: 8190368. DOI: 10.31557/APJCP.2021.22.2.617.

Association of C677T (rs1081133) and A1298C (rs1801131) Methylenetetrahydrofolate Reductase Variants with Breast Cancer Susceptibility Among Asians: A Systematic Review and Meta-Analysis.

Rezaee M, Akbari H, Momeni-Moghaddam M, Moazzen F, Salahi S, Jahankhah R Biochem Genet. 2021; 59(2):367-397.

PMID: 33387129 DOI: 10.1007/s10528-020-10020-z.

MTHFR, XRCC1 and OGG1 genetic polymorphisms in breast cancer: a case-control study in a population from North Sardinia.

Floris M, Sanna D, Castiglia P, Putzu C, Sanna V, Pazzola A BMC Cancer. 2020; 20(1):234.

PMID: 32192442 PMC: 7083022. DOI: 10.1186/s12885-020-06749-w.

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