Forms, Crosstalks, and the Role of Phospholipid Biosynthesis in Autophagy

Overview

Journal Int J Cell Biol

Publisher Wiley

Specialty Cell Biology

Date 2012 Feb 1

PMID 22291708

Citations 14

Authors

Leanne Pereira

John Paul Girardi

Marica Bakovic

Affiliations

Soon will be listed here.

Abstract

Autophagy is a highly conserved cellular process occurring during periods of stress to ensure a cell's survival by recycling cytosolic constituents and making products that can be used in energy generation and other essential processes. Three major forms of autophagy exist according to the specific mechanism through which cytoplasmic material is transported to a lysosome. Chaperone-mediated autophagy is a highly selective form of autophagy that delivers specific proteins for lysosomal degradation. Microautophagy is a less selective form of autophagy that occurs through lysosomal membrane invaginations, forming tubes and directly engulfing cytoplasm. Finally, macroautophagy involves formation of new membrane bilayers (autophagosomes) that engulf cytosolic material and deliver it to lysosomes. This review provides new insights on the crosstalks between different forms of autophagy and the significance of bilayer-forming phospholipid synthesis in autophagosomal membrane formation.

Citing Articles

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