SynaptomeDB: an Ontology-based Knowledgebase for Synaptic Genes

Overview

Journal Bioinformatics

Publisher Oxford University Press

Specialty Biology

Date 2012 Jan 31

PMID 22285564

Citations 70

Authors

Mehdi Pirooznia

Tao Wang

Dimitrios Avramopoulos

David Valle

Gareth Thomas

Richard L Huganir

Fernando S Goes

James B Potash

Peter P Zandi

Affiliations

Soon will be listed here.

Abstract

Motivation: The synapse is integral to the function of the brain and may be an important source of dysfunction underlying many neuropsychiatric disorders. Consequently, it is an excellent candidate for large-scale genomic and proteomic study. However, while the tools and databases available for the annotation of high-throughput DNA and protein are generally robust, a comprehensive resource dedicated to the integration of information about the synapse is lacking.

Results: We present an integrated database, called SynaptomeDB, to retrieve and annotate genes comprising the synaptome. These genes encode components of the synapse including neurotransmitters and their receptors, adhesion/cytoskeletal proteins, scaffold proteins, membrane transporters. SynaptomeDB integrates various and complex data sources for synaptic genes and proteins.

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