DNA Typing for HLA-DPB102 and -DPB104 in Multiple Sclerosis and Juvenile Rheumatoid Arthritis

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 1990 Jan 1

PMID 2228045

Citations 2

Authors

L Fugger

L P Ryder

N Morling

N Odum

J Friis

F K Pedersen

C Heilmann

M Sandberg-Wollheim

A Svejgaard

Affiliations

Soon will be listed here.

Abstract

DP gene typing using in vitro DNA amplification combined with sequence-specific oligonucleotide probes (SSOP) has recently been reported. The amplification step may be specific for the HLA-DPB locus, or it may be specific for one or a group of HLA-DPB alleles, thus increasing the discriminatory power of the system. We report the combined use of group-specific DNA in vitro amplification followed by SSOP in typing for DPB1*02 and DPB1*04 variants. The method was used to type for these variants in 96 randomly selected, healthy Danes, in 37 patients with pauciarticular juvenile rheumatoid arthritis (PJRA), and in 38 patients with multiple sclerosis (MS). Increased frequencies of the cellularly defined HLA-DPw2 in PJRA and of HLA-DPw4 in MS have previously been reported. In the patient groups, the frequencies of the DPB1*02 and DPB1*04 variants did not differ significantly from those expected based on the cellularly defined HLA-DP types of the patients and the frequencies of the DPB1*02 and DPB1*04 variants among healthy Danes.

Citing Articles

DNA polymorphism of HLA class II genes in primary biliary cirrhosis.

Morling N, Dalhoff K, Fugger L, Georgsen J, Jakobsen B, Ranek L Immunogenetics. 1992; 35(2):112-6.

PMID: 1735557 DOI: 10.1007/BF00189520.

Immunogenetics of multiple sclerosis and optic neuritis: DNA polymorphism of HLA class II genes.

Morling N, Sandberg-Wollheim M, Fugger L, Georgsen J, Madsen H, Rieneck K Immunogenetics. 1992; 35(6):391-4.

PMID: 1349586 DOI: 10.1007/BF00179795.

References

Bodmer J, Bodmer W, Heyes J, So A, Tonks S, Trowsdale J . Identification of HLA-DP polymorphism with DP alpha and DP beta probes and monoclonal antibodies: correlation with primed lymphocyte typing. Proc Natl Acad Sci U S A. 1987; 84(13):4596-600. PMC: 305137. DOI: 10.1073/pnas.84.13.4596. View

Fugger L, Morling N, Ryder L, Odum N, Svejgaard A . Technical aspects of typing for HLA-DP alleles using allele-specific DNA in vitro amplification and sequence-specific oligonucleotide probes. Detection of single base mismatches. J Immunol Methods. 1990; 129(2):175-85. DOI: 10.1016/0022-1759(90)90437-z. View

Angelini G, Bugawan T, Delfino L, Erlich H, Ferrara G . HLA-DP typing by DNA amplification and hybridization with specific oligonucleotides. Hum Immunol. 1989; 26(3):169-77. DOI: 10.1016/0198-8859(89)90036-0. View

Fugger L, Morling N, Ryder L, Odum N, Georgsen J, Svejgaard A . Typing for HLA-DPB1*03 and HLA-DPB1*06 using allele-specific DNA in vitro amplification and allele-specific oligonucleotide probes. Detection of "new" DPB1*06 variants. Immunogenetics. 1989; 30(3):208-13. DOI: 10.1007/BF02421208. View

Mitsuishi Y, Urlacher A, Tongio M, Mayer S . Restriction fragment length polymorphism of DP genes defines three new DP alleles. Immunogenetics. 1987; 26(6):383-8. DOI: 10.1007/BF00343711. View

Odum N, Morling N, Friis J, Heilmann C, Jakobsen B, Pedersen F . Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis. Tissue Antigens. 1986; 28(4):245-50. DOI: 10.1111/j.1399-0039.1986.tb00490.x. View

Odum N, Morling N, Sandberg-Wollheim M, Platz P, Svejgaard A . HLA-DP antigens are involved in the susceptibility to multiple sclerosis. Tissue Antigens. 1988; 31(5):235-7. DOI: 10.1111/j.1399-0039.1988.tb02088.x. View

Hoffman R, Shaw S, Francis L, Larson M, Petersen R, Chylack L . HLA-DP antigens in patients with pauciarticular juvenile rheumatoid arthritis. Arthritis Rheum. 1986; 29(9):1057-62. DOI: 10.1002/art.1780290901. View

Rosenberg W, Wordsworth B, Jewell D, Bell J . A locus telomeric to HLA-DPB encodes susceptibility to coeliac disease. Immunogenetics. 1989; 30(4):307-10. DOI: 10.1007/BF02421336. View

10.

Shaw S, Johnson A, Shearer G . Evidence for a new segregant series of B cell antigens that are encoded in the HLA-D region and that stimulate secondary allogenic proliferative and cytotoxic responses. J Exp Med. 1980; 152(3):565-80. PMC: 2185933. DOI: 10.1084/jem.152.3.565. View

11.

Kaufman J, Auffray C, Korman A, Shackelford D, Strominger J . The class II molecules of the human and murine major histocompatibility complex. Cell. 1984; 36(1):1-13. DOI: 10.1016/0092-8674(84)90068-0. View

12.

Bugawan T, Horn G, Long C, Mickelson E, Hansen J, Ferrara G . Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci. J Immunol. 1988; 141(11):4024-30. View

13.

Moen T, Stien R, Bratlie A, Bondevik E . Distribution of HLA-SB antigens in multiple sclerosis. Tissue Antigens. 1984; 24(2):126-7. DOI: 10.1111/j.1399-0039.1984.tb02116.x. View

14.

Morling N, Odum N, Ryder L, Platz P, Jakobsen B, Svejgaard A . Restriction fragment length polymorphism of the HLA-DP subregion and correlations to HLA-DP phenotypes. Proc Natl Acad Sci U S A. 1987; 84(6):1644-8. PMC: 304493. DOI: 10.1073/pnas.84.6.1644. View

15.

Bugawan T, Angelini G, Larrick J, Auricchio S, Ferrara G, Erlich H . A combination of a particular HLA-DP beta allele and an HLA-DQ heterodimer confers susceptibility to coeliac disease. Nature. 1989; 339(6224):470-3. DOI: 10.1038/339470a0. View

16.

Maeda M, Inoko H, Ando A, Uryu N, Nagata Y, Tsuji K . HLA-DP typing by analysis of DNA restriction fragment length polymorphisms in the HLA-DP beta subregion. Hum Immunol. 1988; 21(4):239-48. DOI: 10.1016/0198-8859(88)90033-x. View

17.

Begovich A, Bugawan T, Nepom B, Klitz W, Nepom G, Erlich H . A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis. Proc Natl Acad Sci U S A. 1989; 86(23):9489-93. PMC: 298522. DOI: 10.1073/pnas.86.23.9489. View

18.

Odum N, Hartzman R, Jakobsen B, Morling N, Platz P, ROBBINS F . The HLA-DP polymorphism in Denmark investigated by local and international PLT reagents. Definition of two "new" DP antigens. Tissue Antigens. 1986; 28(2):105-18. DOI: 10.1111/j.1399-0039.1986.tb00468.x. View

19.

Svejgaard A, Platz P, Ryder L . HLA and disease 1982--a survey. Immunol Rev. 1983; 70:193-218. DOI: 10.1111/j.1600-065x.1983.tb00715.x. View

DNA Typing for HLA-DPB1*02 and -DPB1*04 in Multiple Sclerosis and Juvenile Rheumatoid Arthritis

DNA Typing for HLA-DPB102 and -DPB104 in Multiple Sclerosis and Juvenile Rheumatoid Arthritis