Hepatic Injury Induced by Bile Salts: Correlation Between Biochemical and Morphological Events
Overview
Authors
Affiliations
Continuous intravenous infusion of taurochenodeoxycholate at a rate of 0.4 mumol.min-1.100 gm-1 for only 30 min in rats caused threefold to tenfold greater release of proteins (alkaline phosphatase, lactate dehydrogenase and albumin) into bile in comparison with animals infused with tauroursodeoxycholate at much higher rates (1.8 mumol.min-1.100 gm-1) for 2 hr. The simultaneous infusion of tauroursodeoxycholate and taurochenodeoxycholate (0.6 and 0.4 mumol.min-1.100 gm-1, respectively) for 2 hr prevented the marked biochemical changes in the bile induced by taurochenodeoxycholate for 15 to 60 min exhibited significantly more necrotic hepatocytes, especially in zone 1, in comparison with animals infused with tauroursodeoxycholate or a combination of taurochenodeoxycholate and tauroursodeoxycholate. A good correlation was observed between biochemical and morphological indices of bile acid-induced hepatocyte injury. These data suggest that (a) primary events induced by the acute infusion of toxic bile salts responsible for cholestasis include zone 1 hepatocellular necrosis and (b) this can be prevented by the simultaneous infusion of tauroursodeoxycholate.
Cui Y, Guo Y, Kong Y, Zhang G Front Microbiol. 2024; 15:1348027.
PMID: 38601930 PMC: 11004368. DOI: 10.3389/fmicb.2024.1348027.
Loss of Mtm1 causes cholestatic liver disease in a model of X-linked myotubular myopathy.
Karolczak S, Deshwar A, Aristegui E, Kamath B, Lawlor M, Andreoletti G J Clin Invest. 2023; 133(18).
PMID: 37490339 PMC: 10503795. DOI: 10.1172/JCI166275.
Ye L, Ziesch A, Schneider J, Ofner A, Niess H, Denk G Aging Dis. 2023; 15(1):338-356.
PMID: 37307826 PMC: 10796084. DOI: 10.14336/AD.2023.0602.
Roh Y, Kim Y, Lee J, Oh J, Lee S, Laurel Yoon E Life (Basel). 2022; 12(11).
PMID: 36362837 PMC: 9699296. DOI: 10.3390/life12111682.
The Microbiome in Autoimmune Liver Diseases: Metagenomic and Metabolomic Changes.
Zheng Y, Ran Y, Zhang H, Wang B, Zhou L Front Physiol. 2021; 12:715852.
PMID: 34690796 PMC: 8531204. DOI: 10.3389/fphys.2021.715852.