Phaeosphaerins A-F, Cytotoxic Perylenequinones from an Endolichenic Fungus, Phaeosphaeria Sp

Overview

Journal J Nat Prod

Date 2012 Jan 27

PMID 22276650

Citations 14

Authors

Gang Li

Haiying Wang

Rongxiu Zhu

Lingmei Sun

Lining Wang

Ming Li

Yaoyao Li

Yongqing Liu

Zuntian Zhao

Hongxiang Lou

Affiliations

Soon will be listed here.

Abstract

Six novel phototoxins, phaeosphaerins A-F, together with six known perylenequinones were isolated from an endolichenic fungus Phaeosphaeria sp. Their structures were determined unequivocally on the basis of comprehensive analysis of MS and NMR data as well as electronic circular dichroism calculations. These toxins kill cancer cells in vitro with accumulation in lysosomes, and the killing effects were potently intensified in the presence of light.

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