Nuclear Factor-κB Activation in Schwann Cells Regulates Regeneration and Remyelination

Overview

Journal Glia

Specialty Neurology

Date 2012 Jan 26

PMID 22275133

Citations 14

Authors

Paul D Morton

Joshua T Johnstone

Angel Y Ramos

Daniel J Liebl

Mary Bartlett Bunge

John R Bethea

Affiliations

Soon will be listed here.

Abstract

Schwann cells (SCs) are crucial for peripheral nerve development and regeneration; however, the intrinsic regulatory mechanisms governing postinjury responses are poorly understood. Activation and deacetylation of nuclear factor-κB (NF- κB) in SCs have been implicated as prerequisites for peripheral nerve myelination. Using GFAP-IκBα-dn mice in which NF- κB transcriptional activation is inhibited in SCs, we found no discernable differences in the quantity or structure of myelinated axons in adult facial nerves. Following crush injury, axonal regeneration was impaired at 31 days and significantly enhanced at 65 days in transgenic animals. Compact remyelination and Remak bundle organization were significantly compromised at 31 days and restored by 65 days post injury. Together, these data indicate that inhibition of NF-κB activation in SCs transiently delays axonal regeneration and compact remyelination. Manipulating the temporal activation of nuclear factor-κB in Schwann cells may offer new therapeutic avenues for PNS and CNS regeneration.

Citing Articles

Review: Myelin clearance is critical for regeneration after peripheral nerve injury.

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Transcriptional inhibition in Schwann cell development and nerve regeneration.

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Heparin-based coacervate of bFGF facilitates peripheral nerve regeneration by inhibiting endoplasmic reticulum stress following sciatic nerve injury.

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Molecular Mechanisms Involved in Schwann Cell Plasticity.

Boerboom A, Dion V, Chariot A, Franzen R Front Mol Neurosci. 2017; 10:38.

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