Dietary Compounds As Potent Inhibitors of the Signal Transducers and Activators of Transcription (STAT) 3 Regulatory Network

Overview

Journal Genes Nutr

Publisher Biomed Central

Date 2012 Jan 26

PMID 22274779

Citations 16

Authors

Anne Trecul

Franck Morceau

Mario Dicato

Marc Diederich

Affiliations

Soon will be listed here.

Abstract

Signal transducers and activators of transcription (STAT) proteins were described as a family of latent cytosolic transcription factors whose activation is dependent on phosphorylation via growth factor- and cytokine-membrane receptors including interferon and interleukin, or by non-receptor intracellular tyrosine kinases, including Src. A vast majority of natural substances are capable of modulating mitogenic signals, cell survival, apoptosis, cell cycle regulation, angiogenesis as well as processes involved in metastasis development. The inhibition of STAT3 phosphorylation by natural and dietary compounds leads to decreased protein expression of STAT3 targets essentially involved in regulation of the cell cycle and apoptotic cell death. This review details the cell signaling pathways involving STAT transcription factors as well as the corresponding compounds from nature able to interfere with this regulatory system in human cancer.

Citing Articles

Targeting the JAK2/STAT3 Pathway-Can We Compare It to the Two Faces of the God Janus?.

Jaskiewicz A, Domoradzki T, Pajak B Int J Mol Sci. 2020; 21(21).

PMID: 33158194 PMC: 7663396. DOI: 10.3390/ijms21218261.

Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by β-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention.

Di Sotto A, Di Giacomo S, Rubini E, Macone A, Gulli M, Mammola C Cells. 2020; 9(4).

PMID: 32252311 PMC: 7226839. DOI: 10.3390/cells9040858.

STAT3 and STAT5 Targeting for Simultaneous Management of Melanoma and Autoimmune Diseases.

Logotheti S, Putzer B Cancers (Basel). 2019; 11(10).

PMID: 31569642 PMC: 6826843. DOI: 10.3390/cancers11101448.

New sulfurated derivatives of cinnamic acids and rosmaricine as inhibitors of STAT3 and NF-κB transcription factors.

Gabriele E, Brambilla D, Ricci C, Regazzoni L, Taguchi K, Ferri N J Enzyme Inhib Med Chem. 2017; 32(1):1012-1028.

PMID: 28738705 PMC: 6009881. DOI: 10.1080/14756366.2017.1350658.

Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation.

Lu L, Zhang S, Li C, Zhou C, Li D, Liu P Cell Death Dis. 2017; 8(5):e2767.

PMID: 28492557 PMC: 5520699. DOI: 10.1038/cddis.2017.174.

References

Waris G, Siddiqui A . Hepatitis C virus stimulates the expression of cyclooxygenase-2 via oxidative stress: role of prostaglandin E2 in RNA replication. J Virol. 2005; 79(15):9725-34. PMC: 1181604. DOI: 10.1128/JVI.79.15.9725-9734.2005. View

Heinrich P, Behrmann I, Muller-Newen G, Schaper F, Graeve L . Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J. 1998; 334 ( Pt 2):297-314. PMC: 1219691. DOI: 10.1042/bj3340297. View

Weidler M, Rether J, Anke T, Erkel G . Inhibition of interleukin-6 signaling by galiellalactone. FEBS Lett. 2000; 484(1):1-6. DOI: 10.1016/s0014-5793(00)02115-3. View

Sedlacek H, Czech J, Naik R, Kaur G, Worland P, Losiewicz M . Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy. Int J Oncol. 2011; 9(6):1143-68. DOI: 10.3892/ijo.9.6.1143. View

Rajendran P, Li F, Manu K, Shanmugam M, Loo S, Kumar A . γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent. Br J Pharmacol. 2011; 163(2):283-98. PMC: 3087132. DOI: 10.1111/j.1476-5381.2010.01187.x. View

Ilaria Jr R, Van Etten R . P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members. J Biol Chem. 1996; 271(49):31704-10. DOI: 10.1074/jbc.271.49.31704. View

Niwa Y, Kanda H, Shikauchi Y, Saiura A, Matsubara K, Kitagawa T . Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma. Oncogene. 2005; 24(42):6406-17. DOI: 10.1038/sj.onc.1208788. View

Blum W, Phelps M, Klisovic R, Rozewski D, Ni W, Albanese K . Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias. Haematologica. 2010; 95(7):1098-105. PMC: 2895033. DOI: 10.3324/haematol.2009.017103. View

Li F, Rajendran P, Sethi G . Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway. Br J Pharmacol. 2010; 161(3):541-54. PMC: 2990154. DOI: 10.1111/j.1476-5381.2010.00874.x. View

10.

Kassi E, Sourlingas T, Spiliotaki M, Papoutsi Z, Pratsinis H, Aligiannis N . Ursolic acid triggers apoptosis and Bcl-2 downregulation in MCF-7 breast cancer cells. Cancer Invest. 2009; 27(7):723-33. DOI: 10.1080/07357900802672712. View

11.

Grandage V, Gale R, Linch D, Khwaja A . PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways. Leukemia. 2005; 19(4):586-94. DOI: 10.1038/sj.leu.2403653. View

12.

ARGUELLO F, Alexander M, Sterry J, Tudor G, Smith E, Kalavar N . Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts. Blood. 1998; 91(7):2482-90. View

13.

Bharti A, Donato N, Aggarwal B . Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. J Immunol. 2003; 171(7):3863-71. DOI: 10.4049/jimmunol.171.7.3863. View

14.

Li F, Sethi G . Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy. Biochim Biophys Acta. 2010; 1805(2):167-80. DOI: 10.1016/j.bbcan.2010.01.002. View

15.

Kannaiyan R, Shanmugam M, Sethi G . Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer. Cancer Lett. 2010; 303(1):9-20. DOI: 10.1016/j.canlet.2010.10.025. View

16.

Timofeeva O, Gaponenko V, Lockett S, Tarasov S, Jiang S, Michejda C . Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target. ACS Chem Biol. 2007; 2(12):799-809. DOI: 10.1021/cb700186x. View

17.

Duvoix A, Morceau F, Delhalle S, Schmitz M, Schnekenburger M, Galteau M . Induction of apoptosis by curcumin: mediation by glutathione S-transferase P1-1 inhibition. Biochem Pharmacol. 2003; 66(8):1475-83. DOI: 10.1016/s0006-2952(03)00501-x. View

18.

Jing N, Zhu Q, Yuan P, Li Y, Mao L, Tweardy D . Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer. Mol Cancer Ther. 2006; 5(2):279-86. DOI: 10.1158/1535-7163.MCT-05-0302. View

19.

Ozawa Y, Williams A, Estes M, Matsushita N, Boschelli F, Jove R . Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT). Leuk Res. 2008; 32(6):893-903. DOI: 10.1016/j.leukres.2007.11.032. View

20.

Lee S, Lou W, Qureshi K, Mehraein-Ghomi F, Trump D, Gao A . RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells. Prostate. 2004; 60(4):303-9. DOI: 10.1002/pros.20072. View