SNPs in DNA Repair or Oxidative Stress Genes and Late Subcutaneous Fibrosis in Patients Following Single Shot Partial Breast Irradiation

Overview

Journal J Exp Clin Cancer Res

Publisher Biomed Central

Specialty Oncology

Date 2012 Jan 26

PMID 22272830

Citations 11

Authors

Elisabetta Falvo

Lidia Strigari

Gennaro Citro

Carolina Giordano

Genoveva Boboc

Fabiana Fabretti

Vicente Bruzzaniti

Luca Bellesi

Paola Muti

Giovanni Blandino

Paola Pinnaro

Affiliations

Soon will be listed here.

Abstract

Background: The aim of this study was to evaluate the potential association between single nucleotide polymorphisms related response to radiotherapy injury, such as genes related to DNA repair or enzymes involved in anti-oxidative activities. The paper aims to identify marker genes able to predict an increased risk of late toxicity studying our group of patients who underwent a Single Shot 3D-CRT PBI (SSPBI) after BCS (breast conserving surgery).

Methods: A total of 57 breast cancer patients who underwent SSPBI were genotyped for SNPs (single nucleotide polymorphisms) in XRCC1, XRCC3, GST and RAD51 by Pyrosequencing technology. Univariate analysis (ORs and 95% CI) was performed to correlate SNPs with the risk of developing ≥ G2 fibrosis or fat necrosis.

Results: A higher significant risk of developing ≥ G2 fibrosis or fat necrosis in patients with: polymorphic variant GSTP1 (Ile105Val) (OR = 2.9; 95%CI, 0.88-10.14, p = 0.047).

Conclusions: The presence of some SNPs involved in DNA repair or response to oxidative stress seem to be able to predict late toxicity.

Trial Registration: ClinicalTrials.gov: NCT01316328.

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Gong L, Luo M, Sun R, Qiu L, Chen C, Luo Z Front Oncol. 2021; 11:654784.

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Falvo E, Damiani V, Conti G, Boschi F, Messana K, Giacomini P J Exp Clin Cancer Res. 2021; 40(1):63.

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