Different Implications of Paternal and Maternal Atopy for Perinatal IgE Production and Asthma Development

Overview

Journal Clin Dev Immunol

Specialty Allergy & Immunology

Date 2012 Jan 25

PMID 22272211

Citations 12

Authors

Chih-Chiang Wu

Rong-Fu Chen

Ho-Chang Kuo

Affiliations

Soon will be listed here.

Abstract

Asthma is a hereditary disease associated with IgE-mediated reaction. Whether maternal atopy and paternal atopy have different impacts on perinatal IgE production and asthma development remains unclear. This paper reviews and summarizes the effects of maternal and paternal atopy on the developmental aspects of IgE production and asthma. Maternal atopy affects both pre- and postnatal IgE production, whereas paternal atopy mainly affects the latter. Maternally transmitted genes GSTP1 and FceRI-beta are associated with lung function and allergic sensitization, respectively. In IgE production and asthma development, the maternal influence on gene-environment interaction is greater than paternal influence. Maternal, paternal, and/or postnatal environmental modulation of allergic responses have been linked to epigenetic mechanisms, which may be good targets for early prevention of asthma.

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