DNA Repair Gene Variants in Endometrial Carcinoma

Overview

Journal Med Oncol

Publisher Springer

Specialty Oncology

Date 2012 Jan 25

PMID 22271435

Citations 9

Authors

Zeynep Birsu Cincin

Ahmet Cem Iyibozkurt

Sibel Bulgurcuoglu Kuran

Bedia Cakmakoglu

Affiliations

Soon will be listed here.

Abstract

Several polymorphisms in the DNA repair gene are thought to have significant effects on cancer risk. In this study, we investigated the association of the polymorphisms in the DNA repair genes, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys, with endometrium cancer risk. Two hundred and sixty-two women were included in the study. Endometrial biopsy was performed, and on the basis of diagnosis and histological examination, women were divided into two groups: a control group (n=158) and an endometrial cancer group (n=104). Genotypes were determined by PCR-RFLP assays in endometrial carcinoma patients and age-matched controls. In this study, we found that the frequencies of Glu+ and Asp/Glu genotypes in APE, Gln/Gln genotype of XRCC1, Met/Met genotype of XRCC3, Cys+ and Ser/Cys genotypes of HOGG1, His+ and Asp/His genotypes of XPG, and Gln+ and Gln/Gln genotypes of XPD are more prevalent in patients than controls. Frequencies of Thr/Thr genotype in XRCC3 were increased in controls compared with patients and seem to be protected from endometrial cancer. Our findings suggest that XRCC1, XRCC3, XPD, XPG, APE1, and HOGG1 genetic variants may be associated with endometrial cancer in Turkish women.

Citing Articles

XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis.

He S, Zhao X, Mu R, Pan Z, Mai J Open Med (Wars). 2024; 19(1):20240913.

PMID: 38463515 PMC: 10921453. DOI: 10.1515/med-2024-0913.

Association of the hOGG1 Ser326Cys polymorphism with gynecologic cancer susceptibility: a meta-analysis.

Shi Y, Xu W, Zhang X Biosci Rep. 2020; 40(12).

PMID: 33210702 PMC: 7693197. DOI: 10.1042/BSR20203245.

The Investigation of Polymorphisms in DNA Repair Genes (XRCC1, APE1 and XPD) in Women with Polycystic Ovary Syndrome.

Gulbay G, Yesilada E, Celik O, Yologlu S Asian Pac J Cancer Prev. 2017; 18(5):1219-1223.

PMID: 28610405 PMC: 5555526. DOI: 10.22034/APJCP.2017.18.5.1219.

Meta-analysis of XRCC1 polymorphism and risk of female reproductive system cancer.

Yang N, Huang Y, Sun J, Chen Y, Tang Z, Jiang J Oncotarget. 2017; 8(17):28455-28462.

PMID: 28415705 PMC: 5438663. DOI: 10.18632/oncotarget.16090.

Association between the OGG1 Ser326Cys Polymorphism and Cancer Risk: Evidence from 152 Case-Control Studies.

Zou H, Li Q, Xia W, Liu Y, Wei X, Wang D J Cancer. 2016; 7(10):1273-80.

PMID: 27390603 PMC: 4934036. DOI: 10.7150/jca.15035.

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