Predictors of Medication Adherence in Patients with Rheumatoid Arthritis

Overview

Journal Drug Dev Res

Specialty Pharmacology

Date 2012 Jan 24

PMID 22267889

Citations 23

Authors

Elizabeth Salt

Susan K Frazier

Affiliations

Soon will be listed here.

Abstract

Medication adherence is a significant problem in patients with rheumatoid arthritis (RA), a prevalent autoimmune disease. Due to the equivocal results reported in the research, consistent predictors of medication adherence in patients with RA are undetermined. A cross-sectional descriptive, predictive study of 108 patients with RA was used to: 1) describe self-reported medication adherence to disease modifying anti-rheumatic drugs (DMARDs); 2) compare demographic (age, residence, marital status, employment status, years of education, and ethnicity) and clinical (duration of disease and number of medications) factors of adherent and non-adherent individuals; and 3) determine the predictive power of demographic and clinical factors for DMARD adherence using various cut-points (research-based, mean, and median) on a validated, self-report scale measuring medication adherence. Independent samples t-tests, Chi square analyses, and logistic regression modeling were used to analyze these data. Approximately 90% of the individuals with RA reported adherence with their prescribed DMARD prescriptions. The only demographic and clinical difference between the adherent and non-adherent group was ethnicity (p=0.04); nonwhite individuals reported significantly less adherence with their prescribed DMARDs when compared to white individuals. Logistic regression models identified ethnicity (OR= 3.34-10.1; p< 0.05) and the number of medications taken (OR=1.7; p< 0.05) as predictors of medication non-adherence. These data provide evidence that ethnicity and taking an increased number of prescribed medications are independent predictors of medication adherence in patients with RA. These findings confirm the presence of a health disparity and an area where further research is needed to optimize patient outcomes.

Citing Articles

Adherence to the antirheumatic drugs: a systematic review and meta-analysis.

Aksoy N, Ozturk N, Agh T, Kardas P Front Med (Lausanne). 2024; 11:1456251.

PMID: 39328321 PMC: 11424425. DOI: 10.3389/fmed.2024.1456251.

Towards developing a comprehensive treatment schedule for patients with cerebral palsy: factors influencing patient's adherence to physiotherapy treatment.

Ikenna C, Mirian C, Paul C, Onyekachi C, Kingsley K, Chidera L Afr Health Sci. 2022; 22(2):573-580.

PMID: 36407377 PMC: 9652679. DOI: 10.4314/ahs.v22i2.66.

Socioeconomic Status and Medication Use in Rheumatoid Arthritis: A Scoping Review.

Russell O, Lester S, Black R, Hill C Arthritis Care Res (Hoboken). 2022; 75(1):92-100.

PMID: 36106932 PMC: 10100498. DOI: 10.1002/acr.25024.

The relationship between patients' income and education and their access to pharmacological chronic pain management: A scoping review.

Atkins N, Mukhida K Can J Pain. 2022; 6(1):142-170.

PMID: 36092247 PMC: 9450907. DOI: 10.1080/24740527.2022.2104699.

Impact of physician' and pharmacy staff supporting activities in usual care on patients' statin adherence.

Huiskes V, Vriezekolk J, van den Ende C, van Dijk L, van den Bemt B PLoS One. 2022; 17(2):e0264555.

PMID: 35226701 PMC: 8884488. DOI: 10.1371/journal.pone.0264555.

References

Hakala M, Nieminen P, Koivisto O . More evidence from a community based series of better outcome in rheumatoid arthritis. Data on the effect of multidisciplinary care on the retention of functional ability. J Rheumatol. 1994; 21(8):1432-7. View

Garber M, Nau D, Erickson S, Aikens J, Lawrence J . The concordance of self-report with other measures of medication adherence: a summary of the literature. Med Care. 2004; 42(7):649-52. DOI: 10.1097/01.mlr.0000129496.05898.02. View

Hakala M, Nieminen P . Functional status assessment of physical impairment in a community based population with rheumatoid arthritis: severely incapacitated patients are rare. J Rheumatol. 1996; 23(4):617-23. View

Lorish C, Richards B, Brown S . Missed medication doses in rheumatic arthritis patients: intentional and unintentional reasons. Arthritis Care Res. 1989; 2(1):3-9. DOI: 10.1002/anr.1790020103. View

Tuncay R, Eksioglu E, Cakir B, Gurcay E, Cakci A . Factors affecting drug treatment compliance in patients with rheumatoid arthritis. Rheumatol Int. 2007; 27(8):743-6. DOI: 10.1007/s00296-006-0299-9. View

Gabriel S, Crowson C, OFallon W . The epidemiology of rheumatoid arthritis in Rochester, Minnesota, 1955-1985. Arthritis Rheum. 1999; 42(3):415-20. DOI: 10.1002/1529-0131(199904)42:3<415::AID-ANR4>3.0.CO;2-Z. View

Helmick C, Felson D, Lawrence R, Gabriel S, Hirsch R, Kwoh C . Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum. 2008; 58(1):15-25. DOI: 10.1002/art.23177. View

Taal E, Rasker J, Seydel E, Wiegman O . Health status, adherence with health recommendations, self-efficacy and social support in patients with rheumatoid arthritis. Patient Educ Couns. 1993; 20(2-3):63-76. DOI: 10.1016/0738-3991(93)90122-d. View

Viller F, Guillemin F, Briancon S, Moum T, Suurmeijer T, van den Heuvel W . Compliance to drug treatment of patients with rheumatoid arthritis: a 3 year longitudinal study. J Rheumatol. 1999; 26(10):2114-22. View

10.

Owen S, Friesen W, Roberts M, Flux W . Determinants of compliance in rheumatoid arthritic patients assessed in their home environment. Br J Rheumatol. 1985; 24(4):313-20. DOI: 10.1093/rheumatology/24.4.313. View

11.

Doyle D, Perrett D, Foster O, Ensor M, Scott D . The long-term use of D-penicillamine for treating rheumatoid arthritis: is continuous therapy necessary?. Br J Rheumatol. 1993; 32(7):614-7. DOI: 10.1093/rheumatology/32.7.614. View

12.

Salt E, Hall L, Peden A, Home R . Psychometric properties of three medication adherence scales in patients with rheumatoid arthritis. J Nurs Meas. 2012; 20(1):59-72. DOI: 10.1891/1061-3749.20.1.59. View

13.

Clatworthy J, Bowskill R, Parham R, Rank T, Scott J, Horne R . Understanding medication non-adherence in bipolar disorders using a Necessity-Concerns Framework. J Affect Disord. 2008; 116(1-2):51-5. DOI: 10.1016/j.jad.2008.11.004. View

14.

Dunbar-Jacob J, Holmes J, Sereika S, Kwoh C, Burke L, Starz T . Factors associated with attrition of African Americans during the recruitment phase of a clinical trial examining adherence among individuals with rheumatoid arthritis. Arthritis Rheum. 2004; 51(3):422-8. DOI: 10.1002/art.20411. View

15.

Potter T, Mulherin D, Pugh M . Early intervention with disease-modifying therapy for rheumatoid arthritis: where do the delays occur?. Rheumatology (Oxford). 2002; 41(8):953-5; author reply 955. DOI: 10.1093/rheumatology/41.8.953. View

16.

Wang P, Geng G, Badley E . Arthritis prevalence and place of birth: findings from the 1994 Canadian National Population Health Survey. Am J Epidemiol. 2000; 152(5):442-5. DOI: 10.1093/aje/152.5.442. View

17.

de Klerk E, van der Heijde D, Landewe R, van der Tempel H, Urquhart J, van der Linden S . Patient compliance in rheumatoid arthritis, polymyalgia rheumatica, and gout. J Rheumatol. 2003; 30(1):44-54. View

18.

Garcia-Gonzalez A, Richardson M, Garcia Popa-Lisseanu M, Cox V, Kallen M, Janssen N . Treatment adherence in patients with rheumatoid arthritis and systemic lupus erythematosus. Clin Rheumatol. 2008; 27(7):883-9. DOI: 10.1007/s10067-007-0816-6. View

19.

Park D, Hertzog C, Leventhal H, Morrell R, Leventhal E, Birchmore D . Medication adherence in rheumatoid arthritis patients: older is wiser. J Am Geriatr Soc. 1999; 47(2):172-83. DOI: 10.1111/j.1532-5415.1999.tb04575.x. View

20.

Saag K, Doebbeling B, Rohrer J, Kolluri S, Mitchell T, Wallace R . Arthritis health service utilization among the elderly: the role of urban-rural residence and other utilization factors. Arthritis Care Res. 1998; 11(3):177-85. DOI: 10.1002/art.1790110305. View