Nuclear IGF1R is a Transcriptional Co-activator of LEF1/TCF

Overview

Journal EMBO Rep

Specialty Molecular Biology

Date 2012 Jan 21

PMID 22261717

Citations 57

Authors

Dudi Warsito

Sylvia Sjostrom

Sandra Andersson

Olle Larsson

Bita Sehat

Affiliations

Soon will be listed here.

Abstract

Recent findings suggest that nuclear IGF1R binds to enhancer regions and functions as a transcriptional cofactor. However, the downstream transcriptional regulators of this pathway remain to be defined. Here, we show that nuclear IGF1R associates with the transcription factor LEF1 and increases promoter activity of LEF1 downstream target genes cyclin D1 and axin2. Furthermore, nuclear IGF1R augments protein levels of cyclin D1 and axin2. Our findings suggest a novel function for IGF1R, thus further emphasizing the important role of this receptor in cancer biology.

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