Subpopulation Analysis of Heteroresistance to Fluoroquinolone in Mycobacterium Tuberculosis Isolates from Beijing, China

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2012 Jan 20

PMID 22259208

Citations 20

Authors

Xiaobing Zhang

Bing Zhao

Liguo Liu

Yafang Zhu

Yanlin Zhao

Qi Jin

Affiliations

Soon will be listed here.

Abstract

The presence of heteroresistance was represented by 23% of 235 fluoroquinolone (FQ)-resistant Mycobacterium tuberculosis isolates in Beijing, China, from 2008 to 2010. The main mechanism of FQ heteroresistance is due to the segregation of a single M. tuberculosis strain in patients; the majority of isolates with multidrug-resistant tuberculosis contained a mixture of bacterial subpopulations consisting of various mutant types, suggesting that the improper use of FQ is the major cause of FQ resistance.

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