The Contribution of Bone to Whole-organism Physiology

Overview

Journal Nature

Specialty Science

Date 2012 Jan 20

PMID 22258610

Citations 212

Authors

Gerard Karsenty

Mathieu Ferron

Affiliations

Soon will be listed here.

Abstract

The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.

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References

Kaye W, Gendall K, Strober M . Serotonin neuronal function and selective serotonin reuptake inhibitor treatment in anorexia and bulimia nervosa. Biol Psychiatry. 1998; 44(9):825-38. DOI: 10.1016/s0006-3223(98)00195-4. View

Misra M, Klibanski A . The neuroendocrine basis of anorexia nervosa and its impact on bone metabolism. Neuroendocrinology. 2011; 93(2):65-73. PMC: 3214929. DOI: 10.1159/000323771. View

Friedman J, Halaas J . Leptin and the regulation of body weight in mammals. Nature. 1998; 395(6704):763-70. DOI: 10.1038/27376. View

Ferron M, Wei J, Yoshizawa T, Del Fattore A, DePinho R, Teti A . Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell. 2010; 142(2):296-308. PMC: 2910411. DOI: 10.1016/j.cell.2010.06.003. View

Yadav V, Oury F, Suda N, Liu Z, Gao X, Confavreux C . A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell. 2009; 138(5):976-89. PMC: 2768582. DOI: 10.1016/j.cell.2009.06.051. View

Silver I, Murrills R, Etherington D . Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts. Exp Cell Res. 1988; 175(2):266-76. DOI: 10.1016/0014-4827(88)90191-7. View

Bruning J, Michael M, Winnay J, Hayashi T, Horsch D, Accili D . A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell. 1998; 2(5):559-69. DOI: 10.1016/s1097-2765(00)80155-0. View

Bjornholm M, Munzberg H, Leshan R, Villanueva E, Bates S, Louis G . Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest. 2007; 117(5):1354-60. PMC: 1838925. DOI: 10.1172/JCI30688. View

Pollock N, Bernard P, Gower B, Gundberg C, Wenger K, Misra S . Lower uncarboxylated osteocalcin concentrations in children with prediabetes is associated with beta-cell function. J Clin Endocrinol Metab. 2011; 96(7):E1092-9. PMC: 3135188. DOI: 10.1210/jc.2010-2731. View

10.

Modder U, Achenbach S, Amin S, Riggs B, Melton 3rd L, Khosla S . Relation of serum serotonin levels to bone density and structural parameters in women. J Bone Miner Res. 2009; 25(2):415-22. PMC: 3153390. DOI: 10.1359/jbmr.090721. View

11.

GURNEY C . Erythropoietin, erythropoiesis, and the kidney. JAMA. 1960; 173:1828-9. DOI: 10.1001/jama.1960.73020340003013. View

12.

Cornish J, Callon K, Bava U, Lin C, Naot D, Hill B . Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo. J Endocrinol. 2002; 175(2):405-15. DOI: 10.1677/joe.0.1750405. View

13.

Sato S, Hanada R, Kimura A, Abe T, Matsumoto T, Iwasaki M . Central control of bone remodeling by neuromedin U. Nat Med. 2007; 13(10):1234-40. DOI: 10.1038/nm1640. View

14.

Gibson W, Farooqi I, Moreau M, DePaoli A, Lawrence E, ORahilly S . Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy. J Clin Endocrinol Metab. 2004; 89(10):4821-6. DOI: 10.1210/jc.2004-0376. View

15.

Hori M, Shimizu Y, Fukumoto S . Minireview: fibroblast growth factor 23 in phosphate homeostasis and bone metabolism. Endocrinology. 2010; 152(1):4-10. DOI: 10.1210/en.2010-0800. View

16.

Merle B, Delmas P . Normal carboxylation of circulating osteocalcin (bone Gla-protein) in Paget's disease of bone. Bone Miner. 1990; 11(2):237-45. DOI: 10.1016/0169-6009(90)90062-k. View

17.

Yadav V, Balaji S, Suresh P, Liu X, Lu X, Li Z . Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis. Nat Med. 2010; 16(3):308-12. PMC: 2836724. DOI: 10.1038/nm.2098. View

18.

Yang X, Matsuda K, Bialek P, Jacquot S, Masuoka H, Schinke T . ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell. 2004; 117(3):387-98. DOI: 10.1016/s0092-8674(04)00344-7. View

19.

Elefteriou F, Takeda S, Ebihara K, Magre J, Patano N, Kim C . Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci U S A. 2004; 101(9):3258-63. PMC: 365777. DOI: 10.1073/pnas.0308744101. View

20.

Hauschka P, Lian J, Cole D, Gundberg C . Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone. Physiol Rev. 1989; 69(3):990-1047. DOI: 10.1152/physrev.1989.69.3.990. View