A Longitudinal Study of the Association Between Dietary Factors, Serum Lipids, and Bone Marrow Lesions of the Knee

Overview

Journal Arthritis Res Ther

Publisher Biomed Central

Specialty Rheumatology

Date 2012 Jan 20

PMID 22257370

Citations 16

Authors

Dawn Dore

Jonathon de Hoog

Graham Giles

Changhai Ding

Flavia Cicuttini

Graeme Jones

Affiliations

Soon will be listed here.

Abstract

Introduction: Bone marrow lesions (BMLs) play an important role in knee osteoarthritis, but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, serum lipids, and BMLs.

Methods: In total, 394 older men and women (mean age, 63 years; range, 52 to 79) were measured at baseline and approximately 2.7 years later. BMLs were determined by using T2-weighted fat-saturation magnetic resonance imaging (MRI) by measuring the maximal area of the lesion. Nutrient intake (total energy, fat, carbohydrate, protein, and sugar) and serum lipids were assessed at baseline.

Results: Cross-sectionally, dietary factors and lipids were not significantly associated with BMLs. Energy, carbohydrate, and sugar intake (but not fat) were positively associated with a change in BML size (β = 15.44 to 19.27 mm2 per 1 SD increase; all P < 0.05). High-density lipoprotein (HDL) cholesterol tended to be negatively associated with BML change (β = -11.66 mm2 per 1 SD increase; P = 0.088).

Conclusions: Energy, carbohydrate, and sugar intake may be risk factors for BML development and progression. HDL cholesterol seems protective against BMLs. These results suggest that macronutrients and lipids may be important in BML etiology and that dietary modification may alter BML natural history.

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References

Ding C, Garnero P, Cicuttini F, Scott F, Cooley H, Jones G . Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown. Osteoarthritis Cartilage. 2005; 13(3):198-205. DOI: 10.1016/j.joca.2004.11.007. View

Goggs R, Vaughan-Thomas A, Clegg P, Carter S, Innes J, Mobasheri A . Nutraceutical therapies for degenerative joint diseases: a critical review. Crit Rev Food Sci Nutr. 2005; 45(3):145-64. DOI: 10.1080/10408690590956341. View

Bennell K, Creaby M, Wrigley T, Bowles K, Hinman R, Cicuttini F . Bone marrow lesions are related to dynamic knee loading in medial knee osteoarthritis. Ann Rheum Dis. 2009; 69(6):1151-4. DOI: 10.1136/ard.2009.118182. View

Plenk Jr H, Hofmann S, ESCHBERGER J, Gstettner M, Kramer J, Schneider W . Histomorphology and bone morphometry of the bone marrow edema syndrome of the hip. Clin Orthop Relat Res. 1997; (334):73-84. View

Felson D, McLaughlin S, Goggins J, LaValley M, Gale M, Totterman S . Bone marrow edema and its relation to progression of knee osteoarthritis. Ann Intern Med. 2003; 139(5 Pt 1):330-6. DOI: 10.7326/0003-4819-139-5_part_1-200309020-00008. View

Guymer E, Baranyay F, Wluka A, Hanna F, Bell R, Davis S . A study of the prevalence and associations of subchondral bone marrow lesions in the knees of healthy, middle-aged women. Osteoarthritis Cartilage. 2007; 15(12):1437-42. DOI: 10.1016/j.joca.2007.04.010. View

Findlay D . Vascular pathology and osteoarthritis. Rheumatology (Oxford). 2007; 46(12):1763-8. DOI: 10.1093/rheumatology/kem191. View

Conaghan P, Vanharanta H, Dieppe P . Is progressive osteoarthritis an atheromatous vascular disease?. Ann Rheum Dis. 2005; 64(11):1539-41. PMC: 1755271. DOI: 10.1136/ard.2005.039263. View

Hofer T, Fontana L, Anton S, Weiss E, Villareal D, Malayappan B . Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans. Rejuvenation Res. 2008; 11(4):793-9. PMC: 2724865. DOI: 10.1089/rej.2008.0712. View

10.

Fernyhough L, Horwath C, Campbell A, Robertson M, Busby W . Changes in dietary intake during a 6-year follow-up of an older population. Eur J Clin Nutr. 1999; 53(3):216-25. DOI: 10.1038/sj.ejcn.1600704. View

11.

Felson D, Niu J, Guermazi A, Roemer F, Aliabadi P, Clancy M . Correlation of the development of knee pain with enlarging bone marrow lesions on magnetic resonance imaging. Arthritis Rheum. 2007; 56(9):2986-92. DOI: 10.1002/art.22851. View

12.

Li X, Ma B, Bolbos R, Stahl R, Lozano J, Zuo J . Quantitative assessment of bone marrow edema-like lesion and overlying cartilage in knees with osteoarthritis and anterior cruciate ligament tear using MR imaging and spectroscopic imaging at 3 Tesla. J Magn Reson Imaging. 2008; 28(2):453-61. PMC: 2666932. DOI: 10.1002/jmri.21437. View

13.

Davies-Tuck M, Hanna F, Davis S, Bell R, Davison S, Wluka A . Total cholesterol and triglycerides are associated with the development of new bone marrow lesions in asymptomatic middle-aged women - a prospective cohort study. Arthritis Res Ther. 2009; 11(6):R181. PMC: 3003521. DOI: 10.1186/ar2873. View

14.

Hunter D, Zhang Y, Niu J, Goggins J, Amin S, LaValley M . Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis. Arthritis Rheum. 2006; 54(5):1529-35. DOI: 10.1002/art.21789. View

15.

Winet H, Hsieh A, Bao J . Approaches to study of ischemia in bone. J Biomed Mater Res. 1998; 43(4):410-21. DOI: 10.1002/(sici)1097-4636(199824)43:4<410::aid-jbm8>3.0.co;2-b. View

16.

Devaraj S, Wang-Polagruto J, Polagruto J, Keen C, Jialal I . High-fat, energy-dense, fast-food-style breakfast results in an increase in oxidative stress in metabolic syndrome. Metabolism. 2008; 57(6):867-70. PMC: 2692901. DOI: 10.1016/j.metabol.2008.02.016. View

17.

Leydet-Quilici H, Le Corroller T, Bouvier C, Giorgi R, Argenson J, Champsaur P . Advanced hip osteoarthritis: magnetic resonance imaging aspects and histopathology correlations. Osteoarthritis Cartilage. 2010; 18(11):1429-35. DOI: 10.1016/j.joca.2010.08.008. View

18.

Nguyen T, Eisman J . Assessment of significant change in BMD: a new approach. J Bone Miner Res. 2000; 15(2):369-72. DOI: 10.1359/jbmr.2000.15.2.369. View

19.

Zhai G, Blizzard L, Srikanth V, Ding C, Cooley H, Cicuttini F . Correlates of knee pain in older adults: Tasmanian Older Adult Cohort Study. Arthritis Rheum. 2006; 55(2):264-71. DOI: 10.1002/art.21835. View

20.

Altman R, Hochberg M, Murphy Jr W, Wolfe F, Lequesne M . Atlas of individual radiographic features in osteoarthritis. Osteoarthritis Cartilage. 1995; 3 Suppl A:3-70. View