Pathogenesis of AF: Impact on Intracardiac Signals

Overview

Journal Annu Int Conf IEEE Eng Med Biol Soc

Specialty Biomedical Engineering

Date 2012 Jan 19

PMID 22255589

Authors

Ashok J Shah

Remi Dubois

Shinsuke Miyazaki

Amir S Jadidi

Daniel Scherr

Stephen B Wilton

Laurent Roten

Patrizio Pascale

Michala Pedersen

Nicolas Derval

Sebastien Knecht

Frederic Sacher

Pierre Jais

Sanjiv Narayan

Meleze Hocini

Michel Haissaguerre

Affiliations

Soon will be listed here.

Abstract

Atrial fibrillation (AF) is the most common cardiac arrhythmia, and is responsible for the highest number of rhythm-related disorders and cardioembolic strokes worldwide. Intracardiac signal analysis during the onset of paroxysmal AF led to the discovery of pulmonary vein as a triggering source of AF, which has led to the development of pulmonary vein ablation--an established curative therapy for drug-resistant AF. Complex, multicomponent and rapid electrical activity widely involving the atrial substrate characterizes persistent/permanent AF. Widespread nature of the problem and complexity of signals in persistent AF reduce the success rate of ablation therapy. Although signal processing applied to extraction of relevant features from these complex electrograms has helped to improve the efficacy of ablation therapy in persistent/permanent AF, improved understanding of complex signals should help to identify sources of AF and further increase the success rate of ablation therapy.

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