Probabilistic Modeling of Selective Stimulation of the Human Sciatic Nerve with a Flat Interface Nerve Electrode

Overview

Journal Annu Int Conf IEEE Eng Med Biol Soc

Specialty Biomedical Engineering

Date 2012 Jan 19

PMID 22255234

Citations 1

Authors

Matthew A Schiefer

Dustin J Tyler

Ronald J Triolo

Affiliations

Soon will be listed here.

Abstract

Proper ankle control is critical to both standing balance and efficient walking. This study hypothesized that a Flat Interface Nerve Electrode (FINE) placed around the sciatic nerve with a fixed number of contacts at predetermined locations and without a priori knowledge of the nerve's underlying neuroanatomy can selectively control each ankle motion. Models of the human sciatic nerve surrounded by a FINE of varying size were created and used to calculate the probability of selective activation of axons within any arbitrarily designated group of fascicles. Simulations suggest that currently available implantable technology cannot selectively recruit each target plantar flexor individually but can restore plantar flexion or dorsiflexion from a site on the sciatic nerve without spillover to antagonists. Successful activation of individual ankle muscles in 90% of the population can be achieved by utilizing bipolar stimulation and/or by increasing the number of contacts within the cuff.

Citing Articles

Selective Neural Electrical Stimulation of an Injured Facial Nerve Using Chronically Implanted Dual Cuff Electrodes.

Abiri A, Chau S, James N, Goshtasbi K, Birkenbeuel J, Sahyouni R Brain Sci. 2022; 12(11).

PMID: 36358383 PMC: 9688741. DOI: 10.3390/brainsci12111457.

References

Delp S, Anderson F, Arnold A, Loan P, Habib A, John C . OpenSim: open-source software to create and analyze dynamic simulations of movement. IEEE Trans Biomed Eng. 2007; 54(11):1940-50. DOI: 10.1109/TBME.2007.901024. View

Richardson A, McIntyre C, Grill W . Modelling the effects of electric fields on nerve fibres: influence of the myelin sheath. Med Biol Eng Comput. 2000; 38(4):438-46. DOI: 10.1007/BF02345014. View

Tarler M, Mortimer J . Comparison of joint torque evoked with monopolar and tripolar-cuff electrodes. IEEE Trans Neural Syst Rehabil Eng. 2003; 11(3):227-35. DOI: 10.1109/TNSRE.2003.816867. View

. Prevalence of stroke--United States, 2005. MMWR Morb Mortal Wkly Rep. 2007; 56(19):469-74. View

Tyler D, Durand D . Functionally selective peripheral nerve stimulation with a flat interface nerve electrode. IEEE Trans Neural Syst Rehabil Eng. 2003; 10(4):294-303. DOI: 10.1109/TNSRE.2002.806840. View

Grinberg Y, Schiefer M, Tyler D, Gustafson K . Fascicular perineurium thickness, size, and position affect model predictions of neural excitation. IEEE Trans Neural Syst Rehabil Eng. 2009; 16(6):572-81. PMC: 2918421. DOI: 10.1109/TNSRE.2008.2010348. View

Veraart C, Grill W, Mortimer J . Selective control of muscle activation with a multipolar nerve cuff electrode. IEEE Trans Biomed Eng. 1993; 40(7):640-53. DOI: 10.1109/10.237694. View

Branner A, Stein R, Fernandez E, Aoyagi Y, Normann R . Long-term stimulation and recording with a penetrating microelectrode array in cat sciatic nerve. IEEE Trans Biomed Eng. 2004; 51(1):146-57. DOI: 10.1109/TBME.2003.820321. View

McDonnall D, Clark G, Normann R . Interleaved, multisite electrical stimulation of cat sciatic nerve produces fatigue-resistant, ripple-free motor responses. IEEE Trans Neural Syst Rehabil Eng. 2004; 12(2):208-15. DOI: 10.1109/TNSRE.2004.828425. View

10.

Leventhal D, Durand D . Subfascicle stimulation selectivity with the flat interface nerve electrode. Ann Biomed Eng. 2003; 31(6):643-52. DOI: 10.1114/1.1569266. View

11.

Grill Jr W, Mortimer J . Quantification of recruitment properties of multiple contact cuff electrodes. IEEE Trans Rehabil Eng. 1996; 4(2):49-62. DOI: 10.1109/86.506402. View

12.

Kesar T, Perumal R, Reisman D, Jancosko A, Rudolph K, Higginson J . Functional electrical stimulation of ankle plantarflexor and dorsiflexor muscles: effects on poststroke gait. Stroke. 2009; 40(12):3821-7. PMC: 2827197. DOI: 10.1161/STROKEAHA.109.560375. View

13.

Nobunaga A, Go B, Karunas R . Recent demographic and injury trends in people served by the Model Spinal Cord Injury Care Systems. Arch Phys Med Rehabil. 1999; 80(11):1372-82. DOI: 10.1016/s0003-9993(99)90247-2. View

14.

Sweeney J, Ksienski D, Mortimer J . A nerve cuff technique for selective excitation of peripheral nerve trunk regions. IEEE Trans Biomed Eng. 1990; 37(7):706-15. DOI: 10.1109/10.55681. View

15.

McDonnall D, Clark G, Normann R . Selective motor unit recruitment via intrafascicular multielectrode stimulation. Can J Physiol Pharmacol. 2004; 82(8-9):599-609. DOI: 10.1139/y04-047. View

16.

Polasek K, Schiefer M, Pinault G, Triolo R, Tyler D . Intraoperative evaluation of the spiral nerve cuff electrode on the femoral nerve trunk. J Neural Eng. 2009; 6(6):066005. PMC: 2927973. DOI: 10.1088/1741-2560/6/6/066005. View

17.

Schiefer M, Triolo R, Tyler D . A model of selective activation of the femoral nerve with a flat interface nerve electrode for a lower extremity neuroprosthesis. IEEE Trans Neural Syst Rehabil Eng. 2008; 16(2):195-204. PMC: 2920206. DOI: 10.1109/TNSRE.2008.918425. View

18.

Enoka R, Fuglevand A . Motor unit physiology: some unresolved issues. Muscle Nerve. 2001; 24(1):4-17. DOI: 10.1002/1097-4598(200101)24:1<4::aid-mus13>3.0.co;2-f. View

19.

Sladjana U, Ivan J, Bratislav S . Microanatomical structure of the human sciatic nerve. Surg Radiol Anat. 2008; 30(8):619-26. DOI: 10.1007/s00276-008-0386-6. View

20.

Tarler M, Mortimer J . Selective and independent activation of four motor fascicles using a four contact nerve-cuff electrode. IEEE Trans Neural Syst Rehabil Eng. 2004; 12(2):251-7. DOI: 10.1109/tnsre.2004.828415. View