Age-related Disruptions of Circadian Rhythm and Memory in the Senescence-accelerated Mouse (SAMP8)
Overview
Affiliations
Common complaints of the elderly involve impaired cognitive abilities, such as loss of memory and inability to attend. Although much research has been devoted to these cognitive impairments, other factors such as disrupted sleep patterns and increased daytime drowsiness may contribute indirectly to impaired cognitive abilities. Disrupted sleep-wake cycles may be the result of age-related changes to the internal (circadian) clock. In this article, we review recent research on aging and circadian rhythms with a focus on the senescence-accelerated mouse (SAM) as a model of aging. We explore some of the neurobiological mechanisms that appear to be responsible for our aging clock, and consider implications of this work for age-related changes in cognition.
El-Hennamy R, Elmasry H Sleep Biol Rhythms. 2024; 22(2):181-190.
PMID: 38524161 PMC: 10959914. DOI: 10.1007/s41105-023-00495-9.
Polonio A, Medrano M, Chico-Sordo L, Cordova-Oriz I, Cozzolino M, Montans J Aging (Albany NY). 2023; 15(11):4600-4624.
PMID: 37338562 PMC: 10292900. DOI: 10.18632/aging.204731.
Brunswick C, Baldwin D, Bodinayake K, McKenna A, Lo C, Bellfy L Neurobiol Aging. 2023; 126:77-90.
PMID: 36958103 PMC: 10106450. DOI: 10.1016/j.neurobiolaging.2023.02.009.
Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model.
Sanada Y, Ikuta Y, Ding C, Shinohara M, Yimiti D, Ishitobi H Arthritis Res Ther. 2022; 24(1):235.
PMID: 36258202 PMC: 9578281. DOI: 10.1186/s13075-022-02916-5.
Candesartan Effectively Preserves Cognition in Senescence Accelerated Mouse Prone 8 (SAMP8) mice.
Ahmed H, Ishrat T J Alzheimers Dis Rep. 2022; 6(1):257-269.
PMID: 35891637 PMC: 9277674. DOI: 10.3233/ADR-220016.