» Articles » PMID: 22253495

Age-related Disruptions of Circadian Rhythm and Memory in the Senescence-accelerated Mouse (SAMP8)

Overview
Journal Age (Dordr)
Publisher Springer
Specialty Geriatrics
Date 2012 Jan 19
PMID 22253495
Citations 10
Authors
Affiliations
Soon will be listed here.
Abstract

Common complaints of the elderly involve impaired cognitive abilities, such as loss of memory and inability to attend. Although much research has been devoted to these cognitive impairments, other factors such as disrupted sleep patterns and increased daytime drowsiness may contribute indirectly to impaired cognitive abilities. Disrupted sleep-wake cycles may be the result of age-related changes to the internal (circadian) clock. In this article, we review recent research on aging and circadian rhythms with a focus on the senescence-accelerated mouse (SAM) as a model of aging. We explore some of the neurobiological mechanisms that appear to be responsible for our aging clock, and consider implications of this work for age-related changes in cognition.

Citing Articles

Alterations in , gene expression, and oxidative status in aged rats liver after light pulse at night.

El-Hennamy R, Elmasry H Sleep Biol Rhythms. 2024; 22(2):181-190.

PMID: 38524161 PMC: 10959914. DOI: 10.1007/s41105-023-00495-9.


Impaired telomere pathway and fertility in Senescence-Accelerated Mice Prone 8 females with reproductive senescence.

Polonio A, Medrano M, Chico-Sordo L, Cordova-Oriz I, Cozzolino M, Montans J Aging (Albany NY). 2023; 15(11):4600-4624.

PMID: 37338562 PMC: 10292900. DOI: 10.18632/aging.204731.


The clock gene Per1 is necessary in the retrosplenial cortex-but not in the suprachiasmatic nucleus-for incidental learning in young and aging male mice.

Brunswick C, Baldwin D, Bodinayake K, McKenna A, Lo C, Bellfy L Neurobiol Aging. 2023; 126:77-90.

PMID: 36958103 PMC: 10106450. DOI: 10.1016/j.neurobiolaging.2023.02.009.


Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model.

Sanada Y, Ikuta Y, Ding C, Shinohara M, Yimiti D, Ishitobi H Arthritis Res Ther. 2022; 24(1):235.

PMID: 36258202 PMC: 9578281. DOI: 10.1186/s13075-022-02916-5.


Candesartan Effectively Preserves Cognition in Senescence Accelerated Mouse Prone 8 (SAMP8) mice.

Ahmed H, Ishrat T J Alzheimers Dis Rep. 2022; 6(1):257-269.

PMID: 35891637 PMC: 9277674. DOI: 10.3233/ADR-220016.


References
1.
Goergen E, Bagay L, Rehm K, Benton J, Beltz B . Circadian control of neurogenesis. J Neurobiol. 2002; 53(1):90-5. DOI: 10.1002/neu.10095. View

2.
Wise P, Cohen I, Weiland N, London E . Aging alters the circadian rhythm of glucose utilization in the suprachiasmatic nucleus. Proc Natl Acad Sci U S A. 1988; 85(14):5305-9. PMC: 281739. DOI: 10.1073/pnas.85.14.5305. View

3.
Munch M, Knoblauch V, Blatter K, Schroder C, Schnitzler C, Krauchi K . Age-related attenuation of the evening circadian arousal signal in humans. Neurobiol Aging. 2005; 26(9):1307-19. DOI: 10.1016/j.neurobiolaging.2005.03.004. View

4.
Miyamoto M, Kiyota Y, Yamazaki N, Nagaoka A, Matsuo T, Nagawa Y . Age-related changes in learning and memory in the senescence-accelerated mouse (SAM). Physiol Behav. 1986; 38(3):399-406. DOI: 10.1016/0031-9384(86)90112-5. View

5.
Sumova A, Travnickova Z, Illnerova H . Spontaneous c-Fos rhythm in the rat suprachiasmatic nucleus: location and effect of photoperiod. Am J Physiol Regul Integr Comp Physiol. 2000; 279(6):R2262-9. DOI: 10.1152/ajpregu.2000.279.6.R2262. View