The Wisconsin Approach to Newborn Screening for Severe Combined Immunodeficiency

Overview

Journal J Allergy Clin Immunol

Specialty Allergy & Immunology

Date 2012 Jan 17

PMID 22244594

Citations 32

Authors

James Verbsky

Monica Thakar

John Routes

Affiliations

Soon will be listed here.

Abstract

Severe combined immunodeficiency (SCID) is a life-threatening disease of infants that is curable with hematopoietic cell transplantation if detected early. Population-based screening for SCID using the T-cell receptor excision circle (TREC) assay began in Wisconsin in 2008; 5 infants with SCID or other forms of severe T-cell lymphopenia (TCL) have been detected, and no infants with SCID have been missed. This review will provide an overview of the TREC screening assay and an update of the findings from Wisconsin on all infants screened from January 1, 2008, until December 31, 2010. Importantly, we give practical recommendations regarding newborn population-based screening using the TREC assay, including the evaluation and care of infants detected.

Citing Articles

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A Unique Comprehensive Model to Screen Newborns for Severe Combined Immunodeficiency-An Ontario Single-Centre Experience Spanning 2013-2023.

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[Newborn screening for severe combined immunodeficiencies (SCID) in Germany].

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