» Articles » PMID: 22240460

Trends in Reasons for Hospitalization in a Multisite United States Cohort of Persons Living with HIV, 2001-2008

Overview
Date 2012 Jan 14
PMID 22240460
Citations 73
Authors
Affiliations
Soon will be listed here.
Abstract

Introduction: Hospitalization rates for comorbid conditions among persons living with HIV in the current highly active antiretroviral therapy era are unknown.

Methods: Hospitalization data from 2001 to 2008 were obtained on 11,645 adults receiving longitudinal HIV care at 4 geographically diverse US HIV clinics within the HIV Research Network. Modified clinical classification software from the Agency for Healthcare Research and Quality assigned primary ICD-9 codes into diagnostic categories. Analysis was performed with repeated measures negative binomial regression.

Results: During 2001 to 2008, the rate of AIDS-defining illness (ADI) hospitalizations declined from 6.7 to 2.7 per 100 person-years, incidence rate ratio per year, 0.89 (0.87, 0.91). Among the other diagnostic categories with average rates >2 per 100 person-years, cardiovascular hospitalizations increased over time [1.07 (1.03, 1.11)], whereas non-AIDS-defining infection [0.98 (0.96, 1.00)], psychiatric [0.96 (0.93, 1.00)], and gastrointestinal/liver [0.96 (0.92, 1.00)] were slightly decreasing or stable. Although less frequent overall, renal and pulmonary admissions also increased over time in univariate and multivariate analyses. Of all diagnostic categories, ADI admissions had the longest mean length of stay, 10.5 days.

Discussion: ADI hospitalizations have continued to decline in recent years but are still relatively frequent and potentially costly given long lengths of stay. Increases or stability in the rates of chronic end-organ disease admissions imply a need for broader medical knowledge among individual clinicians and/or teams who care for persons living with HIV and a need for long-term access to medications for these conditions.

Citing Articles

Sequelae of Immunocompromised Host Pneumonia.

Salwen B, Mascarenhas E, Horne D, Crothers K, Zifodya J Clin Chest Med. 2025; 46(1):49-60.

PMID: 39890292 PMC: 11790256. DOI: 10.1016/j.ccm.2024.10.004.


Managing Modern Antiretroviral Therapy in the Intensive Care Unit: Overcoming Challenges for Critically Ill People With Human Immunodeficiency Virus.

Chastain D, Tu P, Brizzi M, Keedy C, Baker A, Jackson B Open Forum Infect Dis. 2024; 11(5):ofae213.

PMID: 38715574 PMC: 11075789. DOI: 10.1093/ofid/ofae213.


Longitudinal Analysis of Overlapping Psychosocial Factors Predicting Incident Hospitalization Among Mixed HIV Serostatus Men who have Sex with Men in the Multicenter AIDS Cohort Study.

Qian Y, Detels R, Comulada W, Hidalgo M, Lee S, Biello K AIDS Behav. 2024; 28(9):1-12.

PMID: 38703339 PMC: 11424141. DOI: 10.1007/s10461-024-04356-5.


Hospitalisation rates for youth living with perinatally acquired HIV in England.

Johnson S, Teh J, Pasvol T, Ayres S, Lyall H, Fidler S PLoS One. 2024; 19(3):e0295639.

PMID: 38502654 PMC: 10950242. DOI: 10.1371/journal.pone.0295639.


Hospital Readmissions Among Persons With Human Immunodeficiency Virus in the United States and Canada, 2005-2018: A Collaboration of Cohort Studies.

Davy-Mendez T, Napravnik S, Hogan B, Eron J, Gebo K, Althoff K J Infect Dis. 2023; 228(12):1699-1708.

PMID: 37697938 PMC: 10733730. DOI: 10.1093/infdis/jiad396.


References
1.
Falster K, Wand H, Donovan B, Anderson J, Nolan D, Watson K . Hospitalizations in a cohort of HIV patients in Australia, 1999-2007. AIDS. 2010; 24(9):1329-39. PMC: 2888502. DOI: 10.1097/QAD.0b013e328339e245. View

2.
Martin-Carbonero L, Sanchez-Somolinos M, Garcia-Samaniego J, Nunez M, Valencia M, Gonzalez-Lahoz J . Reduction in liver-related hospital admissions and deaths in HIV-infected patients since the year 2002. J Viral Hepat. 2006; 13(12):851-7. DOI: 10.1111/j.1365-2893.2006.00778.x. View

3.
Crum-Cianflone N, Grandits G, Echols S, Ganesan A, Landrum M, Weintrob A . Trends and causes of hospitalizations among HIV-infected persons during the late HAART era: what is the impact of CD4 counts and HAART use?. J Acquir Immune Defic Syndr. 2010; 54(3):248-57. PMC: 2911973. DOI: 10.1097/qai.0b013e3181c8ef22. View

4.
Krentz H, Gill M . Cost of medical care for HIV-infected patients within a regional population from 1997 to 2006. HIV Med. 2008; 9(9):721-30. DOI: 10.1111/j.1468-1293.2008.00613.x. View

5.
Engsig F, Hansen A, Gerstoft J, Kronborg G, Larsen C, Obel N . Inpatient admissions and outpatient visits in persons with and without HIV infection in Denmark, 1995-2007. AIDS. 2009; 24(3):457-61. DOI: 10.1097/QAD.0b013e328332828d. View