Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients with Pneumococcal Meningitis is Associated with Mortality

Overview

Journal Clin Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2012 Jan 13

PMID 22238165

Citations 22

Authors

Emma C Wall

Stephen B Gordon

Samia Hussain

Upali R S Goonetilleke

Jenna Gritzfeld

Matthew Scarborough

Aras Kadioglu

Affiliations

Soon will be listed here.

Abstract

Poor prognosis in Pneumococcal meningitis may be associated with high pneumolysin levels in cerebrospinal fluid (CSF). In patient samples we showed that pneumolysin levels in CSF remained high after 48 hours in nonsurvivors of meningitis compared with survivors. Selective antipneumolysin treatment may present a novel therapeutic option.

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