Yaws in the Western Pacific Region: a Review of the Literature

Overview

Journal J Trop Med

Publisher Wiley

Specialty Tropical Medicine

Date 2012 Jan 12

PMID 22235208

Citations 7

Authors

Corinne Capuano

Masayo Ozaki

Affiliations

Soon will be listed here.

Abstract

Until the middle of the 20th century, yaws was highly endemic and considered a serious public health problem in the Western Pacific Region (WPR), leading to intensive control efforts in the 1950s-1960s. Since then, little attention has been paid to its reemergence. Its current burden is unknown. This paper presents the results of an extensive literature review, focusing on yaws in the South Pacific. Available records suggest that the region remains largely free of yaws except for Papua New Guinea, Solomon Islands, and Vanuatu. Many clinical cases reported recently were described as "attenuated"; advanced stages are rare. A single intramuscular injection of benzathine penicillin is still effective in curing yaws. In the Pacific, yaws may be amenable to elimination if adequate resources are provided and political commitment revived. A mapping of yaws prevalence in PNG, Solomon, and Vanuatu is needed before comprehensive country-tailored strategies towards yaws elimination can be developed.

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References

Backhouse J, Hudson B, Hamilton P, Nesteroff S . Failure of penicillin treatment of yaws on Karkar Island, Papua New Guinea. Am J Trop Med Hyg. 1998; 59(3):388-92. DOI: 10.4269/ajtmh.1998.59.388. View

Hudson B, Backhouse J, Tscharke E . Management of yaws in Papua New Guinea. P N G Med J. 1990; 33(1):59-65. View

Manning L, Ogle G . Yaws in the periurban settlements of Port Moresby, Papua New Guinea. P N G Med J. 2003; 45(3-4):206-12. View

Mohamed K . Imported yaws in Johor, Malaysia. Ann Trop Paediatr. 1988; 8(4):222-4. DOI: 10.1080/02724936.1988.11748575. View

Hopkins D . Control of yaws and other endemic treponematoses: implementation of vertical and/or integrated programs. Rev Infect Dis. 1985; 7 Suppl 2:S338-42. DOI: 10.1093/clinids/7-supplement_2.s338. View

Rinaldi A . Yaws: a second (and maybe last?) chance for eradication. PLoS Negl Trop Dis. 2008; 2(8):e275. PMC: 2565700. DOI: 10.1371/journal.pntd.0000275. View

Garner P, Talwat E, Hill G, Reid M, Garner M . Yaws reappears. P N G Med J. 1986; 29(3):247-52. View

Woznicova V, Matejkova P, Flasarova M, Zakoucka H, Valisova Z, Smajs D . Clarithromycin treatment failure due to macrolide resistance in Treponema pallidum in a patient with primary syphilis. Acta Derm Venereol. 2010; 90(2):206-7. DOI: 10.2340/00015555-0774. View

Levrero F, Gatti S, Gautier-Hion A, Menard N . Yaws disease in a wild gorilla population and its impact on the reproductive status of males. Am J Phys Anthropol. 2007; 132(4):568-75. DOI: 10.1002/ajpa.20560. View

10.

Garner M, Hornabrook R . Treponematosis in the eastern highlands of New Guinea. Bull World Health Organ. 1968; 38(2):189-95. PMC: 2554315. View

11.

Harris M, Nako D, Hopkins T, Powell D, Kenny C, Carroll C . Yaws infection in Tanna, Vanuatu 1989. Southeast Asian J Trop Med Public Health. 1991; 22(1):113-9. View

12.

Martin I, Tsang R, Sutherland K, Tilley P, Read R, Anderson B . Molecular characterization of syphilis in patients in Canada: azithromycin resistance and detection of Treponema pallidum DNA in whole-blood samples versus ulcerative swabs. J Clin Microbiol. 2009; 47(6):1668-73. PMC: 2691066. DOI: 10.1128/JCM.02392-08. View

13.

Lo E . Yaws in Malaysia. Rev Infect Dis. 1985; 7 Suppl 2:S251-3. DOI: 10.1093/clinids/7-supplement_2.s251. View

14.

Eason R, Henry A, Somerfield S, Jones G . Resurgent yaws in the Solomon Islands. Aust N Z J Med. 1985; 15(6):727-30. View

15.

Farnsworth N, Rosen T . Endemic treponematosis: review and update. Clin Dermatol. 2006; 24(3):181-90. DOI: 10.1016/j.clindermatol.2005.11.004. View

16.

Meheus A . Integration of yaws control and primary health care. Rev Infect Dis. 1985; 7 Suppl 2:S284-8. DOI: 10.1093/clinids/7-supplement_2.s284. View

17.

Fegan D, Glennon M, Thami Y, Pakoa G . Resurgence of yaws in Tanna, Vanuatu: time for a new approach?. Trop Doct. 2010; 40(2):68-9. DOI: 10.1258/td.2009.090249. View

18.

Wallace A, Ellis J . Juxta-articular bone lesions in tertiary yaws. Med J Aust. 1989; 150(4):217-9. DOI: 10.5694/j.1326-5377.1989.tb136432.x. View

19.

Asiedu K, Amouzou B, Dhariwal A, Karam M, Lobo D, Patnaik S . Yaws eradication: past efforts and future perspectives. Bull World Health Organ. 2008; 86(7):499-499A. PMC: 2647478. DOI: 10.2471/blt.08.055608. View

20.

Gip L . Yaws revisited. Med J Malaysia. 1989; 44(4):307-11. View