The Influence of Age on N-isopropyl-p-[123I]iodoamphetamine Accumulation in the Human Heart

Overview

Journal Ann Nucl Med

Date 1990 Jul 1

PMID 2223378

Authors

M Nakajo

Y Nakabeppu

S Iwashita

S Shinohara

Affiliations

Soon will be listed here.

Abstract

Variations in heart intensity in the 30 min and 4 hr chest images of the radiolabelled lipophilic amine, N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) were observed in 130 patients with lung diseases, aged 23 to 85 yrs. The heart intensity had a significant positive linear correlation with age (r = 0.43 at 30 min, 0.66 at 4 hr). The ratio of 4 hr heart intensity to 30 min heart intensity also had a positive linear correlation (r = 0.59), suggesting slower clearance of the radioactivity from the heart in older than in younger patients during this interval. Other parameters including sex, EKG findings, liver function, blood pressure, the presence of diabetes mellitus and smoking history had no relationship to heart intensity. A significant difference between heart intensities in bronchogenic carcinoma and pneumonia patient groups might be probably due to the age difference between the two groups. Therefore heart intensity in the 4 hr 123I-IMP image may reflect certain metabolic and/or myocardial change(s) with aging.

References

Hill T, HOLMAN B, Lovett R, OLeary D, Front D, Magistretti P . Initial experience with SPECT (single-photon computerized tomography) of the brain using N-isopropyl I-123 p-iodoamphetamine: concise communication. J Nucl Med. 1982; 23(3):191-5. View

Rahimian J, Glass E, TOUYA J, Akber S, Graham L, BENNETT L . Measurement of metabolic extraction of tracers in the lung using a multiple indicator dilution technique. J Nucl Med. 1984; 25(1):31-7. View

TOUYA J, Rahimian J, Grubbs D, CORBUS H, BENNETT L . A noninvasive procedure for in vivo assay of a lung amine endothelial receptor. J Nucl Med. 1985; 26(11):1302-7. View

Ambani L, Jhung J, Edelstein L, VAN WOERT M . Quantification of melanin in hepatic and cardiac lipofuscin. Experientia. 1977; 33(3):296-8. DOI: 10.1007/BF02002788. View

Schwartz J, Abernethy D . Cardiac drugs: adjusting their use in aging patients. Geriatrics. 1987; 42(8):31-4, 37-40. View

Lee R, Hill T, HOLMAN B, Uren R, Clouse M . Comparison of N-isopropyl (I-123) p-iodoamphetamine brain scans using Anger camera scintigraphy and single-photon emission tomography. Radiology. 1982; 145(3):789-93. DOI: 10.1148/radiology.145.3.6983088. View

von Schulthess G, KETZ E, Schubiger P, Bekier A . Regional quantitative noninvasive assessment of cerebral perfusion and function with N-isopropyl-[123I]p-iodoamphetamine. J Nucl Med. 1985; 26(1):9-16. View

Nakajo M, Shimada J, Shimozono M, Uchiyama N, Hiraki Y, Shinohara S . [Serial lung imaging with 123I-IMP in localized pulmonary lesions]. Kaku Igaku. 1988; 25(5):441-50. View

HOLMAN B, Zimmerman R, Schapiro J, Kaplan M, Jones A, Hill T . Biodistribution and dosimetry of N-isopropyl-p-[123I]iodoamphetamine in the primate. J Nucl Med. 1983; 24(10):922-31. View

10.

Moretti J, HOLMAN B, Delmon L, Carmel A, Johnson D, Moingeon P . Effect of antidepressant and narcoleptic drugs on N-isopropyl p-iodoamphetamine biodistribution in animals. J Nucl Med. 1987; 28(3):354-9. View

11.

HOLMAN B, Wick M, Kaplan M, Hill T, Lee R, Wu J . The relationship of the eye uptake of N-isopropyl-p-[123I]iodoamphetamine to melanin production. J Nucl Med. 1984; 25(3):315-9. View

12.

Strehler B, MARK D, Mildvan A . GEE MV: Rate and magnitude of age pigment accumulation in the human myocardium. J Gerontol. 1959; 14:430-9. DOI: 10.1093/geronj/14.4.430. View

13.

Nakajo M, Uchiyama N, Hiraki Y, Miyata Y, Iriki A, Hirotsu Y . Increased accumulation of iodine-123-IMP in the pulmonary inflammatory lesion surrounding a lung cancer. Ann Nucl Med. 1988; 2(1):49-53. DOI: 10.1007/BF03164586. View

14.

WINCHELL H, HORST W, Braun L, Oldendorf W, HATTNER R, Parker H . N-isopropyl-[123I] p-iodoamphetamine: single-pass brain uptake and washout; binding to brain synaptosomes; and localization in dog and monkey brain. J Nucl Med. 1980; 21(10):947-52. View

15.

WINCHELL H, Baldwin R, Lin T . Development of I-123-labeled amines for brain studies: localization of I-123 iodophenylalkyl amines in rat brain. J Nucl Med. 1980; 21(10):940-6. View

16.

Thoenen H, Hurlimann A, Haefely W . Mechanism of amphetamine accumulation in the isolated perfused heart of the rat. J Pharm Pharmacol. 1968; 20(1):1-11. DOI: 10.1111/j.2042-7158.1968.tb09611.x. View

17.

Obianwu H, Stitzel R, Lundborg P . Subcellular distribution of [3H]amphetamine and [3H]guanethidine and their interaction with adrenergic neurons. J Pharm Pharmacol. 1968; 20(8):585-94. DOI: 10.1111/j.2042-7158.1968.tb09818.x. View

18.

Baldwin R, Wu J . In vivo chemistry of iofetamine HCl iodine-123 (IMP). J Nucl Med. 1988; 29(1):122-4. View