Malignant Melanoma As Second Malignant Neoplasm in Long-term Childhood Cancer Survivors: a Systematic Review

Overview

Journal Pediatr Blood Cancer

Specialties Hematology
Oncology
Pediatrics

Date 2012 Jan 11

PMID 22232079

Citations 15

Authors

Katja I Braam

Annelies Overbeek

Gertjan J L Kaspers

Cecile M Ronckers

Annette Y N Schouten-van Meeteren

Eline van Dulmen-den Broeder

Margreet A Veening

Affiliations

Soon will be listed here.

Abstract

This systematic review provides information on malignant melanoma as second malignant neoplasm (SMN) after childhood cancer and evaluates its risk factors. Study reports describing incidences of SMN and malignant melanoma as SMN in a population of childhood cancer survivors (CCS) were included. Of 151,575 CCS, 4,010 (2.6%) children developed an SMN, 212 of which were melanoma (5.3% or 0.14% of all CCS). The following risk factors for malignant melanoma as SMN were identified: radiotherapy, or the combination alkylating agents and anti-mitotic drugs. Melanomas are most frequently observed after Hodgkin disease, hereditary retinoblastoma, soft tissue sarcoma, and gonadal tumors.

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