» Articles » PMID: 22229101

Review of Breast Conservation Therapy: then and Now

Overview
Journal ISRN Oncol
Specialty Oncology
Date 2012 Jan 10
PMID 22229101
Citations 8
Authors
Affiliations
Soon will be listed here.
Abstract

Breast conservation therapy (BCT), which is the marriage of breast conserving surgery and radiation therapy to the breast, has revolutionized the treatment of breast cancer over the last few decades. Surgical direction had seen a heightened interest in the performance of cosmetically superior partial and segmental resections in breast conservation as well as increased demand by patients for breast preservation. The broadening of approaches to delivery of breast irradiation from whole breast to accelerated partial breast has allowed more patients to opt for breast conservation and allowed for what appears to be comparable measurable outcomes in emerging data. As well, the addition of state-of-the-art chemotherapeutic and hormonal therapies has allowed improved outcomes of patients from both local regional recurrence and overall survival standpoints. This paper will provide an overview of BCT and review some of the newest developments in optimizing this therapy for patients with breast cancer from a surgical-, medical-, and radiation-oncology standpoint.

Citing Articles

Global prevalence and factors associated with preoperative depression in women undergoing breast surgery: a meta-analysis and meta-regression.

Leo C, Cheng L, Lam X, He H Breast Cancer Res Treat. 2024; 205(3):425-438.

PMID: 38492162 DOI: 10.1007/s10549-023-07216-3.


Therapeutic mammoplasty: a "wise" oncoplastic choice-lessons from the largest single-center cohort from Asia.

Koppiker C, Joshi S, Mishra R, Kelkar D, Chigurupati P, Joshi A Front Oncol. 2023; 13:1131951.

PMID: 37124516 PMC: 10141318. DOI: 10.3389/fonc.2023.1131951.


Image-Guided Breast Interventions: Biopsy and Beyond.

Dhamija E, Singh R, Mishra S, Hari S Indian J Radiol Imaging. 2021; 31(2):391-399.

PMID: 34556924 PMC: 8448213. DOI: 10.1055/s-0041-1734223.


The Importance of Alexithymia in Post-surgery. Differences on Body Image and Psychological Adjustment in Breast Cancer Patients.

Gutierrez Hermoso L, Velasco Furlong L, Sanchez-Roman S, Salas Costumero L Front Psychol. 2021; 11:604004.

PMID: 33391123 PMC: 7775299. DOI: 10.3389/fpsyg.2020.604004.


Trends of mastectomy and breast-conserving surgery and related factors in female breast cancer patients treated at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, 2009-2017: A retrospective cohort study.

Al-Gaithy Z, Yaghmoor B, Koumu M, Alshehri K, Saqah A, Alshehri H Ann Med Surg (Lond). 2019; 41:47-52.

PMID: 31245000 PMC: 6582239. DOI: 10.1016/j.amsu.2019.03.012.


References
1.
Ellis M, Tao Y, Luo J, AHern R, Evans D, Bhatnagar A . Outcome prediction for estrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumor characteristics. J Natl Cancer Inst. 2008; 100(19):1380-8. PMC: 2556704. DOI: 10.1093/jnci/djn309. View

2.
Vicini F, Antonucci J, Wallace M, Gilbert S, Goldstein N, Kestin L . Long-term efficacy and patterns of failure after accelerated partial breast irradiation: a molecular assay-based clonality evaluation. Int J Radiat Oncol Biol Phys. 2007; 68(2):341-6. DOI: 10.1016/j.ijrobp.2006.12.007. View

3.
Sioshansi S, Rivard M, Hiatt J, Hurley A, Lee Y, Wazer D . Dose modeling of noninvasive image-guided breast brachytherapy in comparison to electron beam boost and three-dimensional conformal accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys. 2010; 80(2):410-6. DOI: 10.1016/j.ijrobp.2010.01.052. View

4.
van Nes J, Putter H, Julien J, Tubiana-Hulin M, Van de Vijver M, Bogaerts J . Preoperative chemotherapy is safe in early breast cancer, even after 10 years of follow-up; clinical and translational results from the EORTC trial 10902. Breast Cancer Res Treat. 2008; 115(1):101-13. DOI: 10.1007/s10549-008-0050-1. View

5.
Katz A, Saad E, Porter P, Pusztai L . Primary systemic chemotherapy of invasive lobular carcinoma of the breast. Lancet Oncol. 2007; 8(1):55-62. DOI: 10.1016/S1470-2045(06)71011-7. View