IL-13 Polymorphisms Contribute to the Risk of Asthma: a Meta-analysis

Overview

Journal Clin Biochem

Specialty Biochemistry

Date 2012 Jan 7

PMID 22222605

Citations 24

Authors

Lin Cui

Jing Jia

Chun-fen Ma

Su-Yun Li

You-Ping Wang

Xiao-Min Guo

Qiang Li

Hai-Bin Yu

Wei-Hong Liu

Lin-Bo Gao

Affiliations

Soon will be listed here.

Abstract

Objectives: The purpose of this study was to evaluate the effects of interleukin-13 (IL-13) polymorphisms on the risk of asthma using a meta-analysis.

Design And Methods: Fifteen publications were identified by searching Pubmed, Embase, ISI, OVID, and EBSCO databases. Odds ratios with corresponding 95% confidence intervals were computed to estimate the association between IL-13 polymorphisms and risk of asthma.

Results: The polymorphisms of R130Q (rs20541) and -1112C/T (rs1800925) in IL-13 gene were associated with significantly increased risks of asthma in overall analyses. Subgroup analyses showed that the elevated risks occurred in adult-onset asthma, Caucasians, and high quality studies.

Conclusions: This meta-analysis provides evidence that the R130Q and -1112C/T polymorphisms in IL-13 are risk factors for asthma.

Citing Articles

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Association of interleukin-13 gene single nucleotide polymorphism rs1800925 with allergic asthma in Asian population: A meta-analysis.

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