In Vitro Biocompatibility of Thermally Gelling Liquid Mucoadhesive Loaded Curcuminoids in Colorectal Cancer Chemoprevention

Overview

Journal Int J Colorectal Dis

Specialties Gastroenterology
General Surgery

Date 2012 Jan 7

PMID 22222465

Citations 13

Authors

Ming-Jenn Chen

Ya-Min Cheng

Pei-Heng Lai

June-Fu Wu

Yi-Chiang Hsu

Affiliations

Soon will be listed here.

Abstract

Purpose: Colorectal cancer (CRC) is the third leading cause of cancer death in Taiwan; it ranks top three in the cancer mortality rate. Curcuminoids are derived from the rhizome of Curcuma longa. It has shown anti-cancer activity and apoptosis induction in a variety of cancer cell lines. This aims to study the potential of Poloxamer 407 as the thermogelling and mucoadhesive polymer for development of a site-targeting delivery system to enhance the localized delivery of curcuminoids to the colorectal cells for CRC chemotherapy.

Methods: The mucoadhesive strength and rheological properties were measured as a function of poloxamer loaded with curcuminoids.

Results: The gelation temperature of Poloxamer 407 was found to vary with its concentration and start gelling at 37°C at the concentration of 15.5% (w/v). To ensure gelation at physiological temperature after intra-rectal application, gelation temperature was determined by rheological measurement as well as by its physical appearance. The results indicated that its mucoadhesive strength also shows a dependency on temperature, which appears to be related to the increment in the maximum strength and average strength of the polymer.

Conclusion: The results have suggested that Poloxamer 407 could be a potential thermogelling and mucoadhesive polymer for the development of a site-targeting colorectal drug delivery system for curcuminoids in colorectal cancer therapy.

Citing Articles

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A Comprehensive Review on the Therapeutic Potential of Linn. in Relation to its Major Active Constituent Curcumin.

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Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview.

Giuliano E, Paolino D, Fresta M, Cosco D Pharmaceutics. 2018; 10(3).

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