Synthesis of New 4,5-dihydrofuranoindoles and Their Evaluation As HCV NS5B Polymerase Inhibitors
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The synthesis of substituted 3,4-dihydrofuranoindoles is reported. These new indole compounds were used to synthesize potent HCV NS5B inhibitors. The binding mode of the dihydrofuranoindole-derived inhibitors was established via X-ray crystallographic studies.
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