Human Polymorphisms As Clinical Predictors in Leprosy

Overview

Journal J Trop Med

Publisher Wiley

Specialty Tropical Medicine

Date 2012 Jan 6

PMID 22220182

Citations 3

Authors

Ernesto Prado Montes de Oca

Affiliations

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Abstract

Genetic and serum markers in human host can predict leprosy susceptibility per se as well as be useful in classification and/or prediction of clinical variants and immunological responses in leprosy. Adequate and timely assessment of potential risks associated with these 38 host leprosy genes could diminish epidemiological burden and improve life quality of patients with this still prevalent mycobacterial disease.

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References

Ranque B, Alcais A, Van Thuc N, Woynard S, Thai V, Huong N . A recessive major gene controls the mitsuda reaction in a region endemic for leprosy. J Infect Dis. 2005; 192(8):1475-82. DOI: 10.1086/466535. View

Kang T, Chae G . Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. FEMS Immunol Med Microbiol. 2001; 31(1):53-8. DOI: 10.1111/j.1574-695X.2001.tb01586.x. View

Kocak M, Balci M, Pence B, Kundakci N . Associations between human leukocyte antigens and leprosy in the Turkish population. Clin Exp Dermatol. 2002; 27(3):235-9. DOI: 10.1046/j.1365-2230.2002.01004.x. View

Modlin R . The innate immune response in leprosy. Curr Opin Immunol. 2010; 22(1):48-54. PMC: 2882026. DOI: 10.1016/j.coi.2009.12.001. View

Ranque B, Nguyen V, Vu H, Nguyen T, Nguyen N, Pham X . Age is an important risk factor for onset and sequelae of reversal reactions in Vietnamese patients with leprosy. Clin Infect Dis. 2006; 44(1):33-40. DOI: 10.1086/509923. View

Scollard D, Adams L, Gillis T, Krahenbuhl J, Truman R, Williams D . The continuing challenges of leprosy. Clin Microbiol Rev. 2006; 19(2):338-81. PMC: 1471987. DOI: 10.1128/CMR.19.2.338-381.2006. View

Bochud P, Hawn T, Siddiqui M, Saunderson P, Britton S, Abraham I . Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy. J Infect Dis. 2008; 197(2):253-61. PMC: 3077295. DOI: 10.1086/524688. View

Prado-Montes De Oca E . Human beta-defensin 1: a restless warrior against allergies, infections and cancer. Int J Biochem Cell Biol. 2010; 42(6):800-4. DOI: 10.1016/j.biocel.2010.01.021. View

Jabado N, Jankowski A, Dougaparsad S, Picard V, Grinstein S, Gros P . Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane. J Exp Med. 2000; 192(9):1237-48. PMC: 2193348. DOI: 10.1084/jem.192.9.1237. View

10.

Liu X, Wu H, Byrne M, Krane S, Jaenisch R . Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A. 1997; 94(5):1852-6. PMC: 20006. DOI: 10.1073/pnas.94.5.1852. View

11.

Kulkarni S, Martin M, Carrington M . The Yin and Yang of HLA and KIR in human disease. Semin Immunol. 2008; 20(6):343-52. PMC: 3501819. DOI: 10.1016/j.smim.2008.06.003. View

12.

Meisner S, Mucklow S, Warner G, Sow S, Lienhardt C, Hill A . Association of NRAMP1 polymorphism with leprosy type but not susceptibility to leprosy per se in west Africans. Am J Trop Med Hyg. 2002; 65(6):733-5. DOI: 10.4269/ajtmh.2001.65.733. View

13.

Fitness J, Tosh K, Hill A . Genetics of susceptibility to leprosy. Genes Immun. 2002; 3(8):441-53. DOI: 10.1038/sj.gene.6363926. View

14.

Matsuoka M . Drug resistance in leprosy. Jpn J Infect Dis. 2010; 63(1):1-7. View

15.

Tosh K, Meisner S, Siddiqui M, Balakrishnan K, Ghei S, Golding M . A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population. J Infect Dis. 2002; 186(8):1190-3. DOI: 10.1086/343806. View

16.

Groathouse N, Rivoire B, Kim H, Lee H, Cho S, Brennan P . Multiple polymorphic loci for molecular typing of strains of Mycobacterium leprae. J Clin Microbiol. 2004; 42(4):1666-72. PMC: 387587. DOI: 10.1128/JCM.42.4.1666-1672.2004. View

17.

Sarker P, Ahmed S, Tiash S, Rekha R, Stromberg R, Andersson J . Phenylbutyrate counteracts Shigella mediated downregulation of cathelicidin in rabbit lung and intestinal epithelia: a potential therapeutic strategy. PLoS One. 2011; 6(6):e20637. PMC: 3108617. DOI: 10.1371/journal.pone.0020637. View

18.

de Messias I, Santamaria J, Brenden M, Reis A, Mauff G . Association of C4B deficiency (C4B*Q0) with erythema nodosum in leprosy. Clin Exp Immunol. 1993; 92(2):284-7. PMC: 1554813. DOI: 10.1111/j.1365-2249.1993.tb03393.x. View

19.

Oliveira R, Ochoa M, Sieling P, Rea T, Rambukkana A, Sarno E . Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy. Infect Immun. 2003; 71(3):1427-33. PMC: 148832. DOI: 10.1128/IAI.71.3.1427-1433.2003. View

20.

Abecasis G, Altshuler D, Auton A, Brooks L, Durbin R, Gibbs R . A map of human genome variation from population-scale sequencing. Nature. 2010; 467(7319):1061-73. PMC: 3042601. DOI: 10.1038/nature09534. View