Role of Thiamine in Alzheimer's Disease

Overview

Journal Am J Alzheimers Dis Other Demen

Publisher Sage Publications

Specialty Neurology

Date 2012 Jan 6

PMID 22218733

Citations 14

Authors

Khanh Vinh Quoc Luong

Lan Thi Hoang Nguyen

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD) is the most common form of dementia in elderly individuals and is associated with progressive neurodegeneration of the human neocortex. Thiamine levels and the activity of thiamine-dependent enzymes are reduced in the brains and peripheral tissues of patients with AD. Genetic studies have provided the opportunity to determine what proteins link thiamine to AD pathology (ie, transketolase, apolipoprotein E, α-1-antitrypsin, pyruvate dehydrogenase complex, p53, glycogen synthetase kinase-3β, c-Fos gene, the Sp1 promoter gene, and the poly(ADP-ribosyl) polymerase-1 gene). We reviewed the association between histopathogenesis and neurotransmitters to understand the relationship between thiamine and AD pathology. Oral thiamine trials have been shown to improve the cognitive function of patients with AD; however, absorption of thiamine is poor in elderly individuals. In the early stage of thiamine-deficient encephalopathy (Wernicke's encephalopathy), however, parental thiamine has been used successfully. Therefore, further studies are needed to determine the benefits of using parental thiamine as a treatment for AD.

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References

Zhao J, Sun X, Yu Z, Pan X, Gu F, Chen J . Exposure to pyrithiamine increases β-amyloid accumulation, Tau hyperphosphorylation, and glycogen synthase kinase-3 activity in the brain. Neurotox Res. 2010; 19(4):575-83. DOI: 10.1007/s12640-010-9204-0. View

McRee R, Langlais P, Chen Y, Nalwalk J, Blumenstock F, Hough L . Increased histamine release and granulocytes within the thalamus of a rat model of Wernicke's encephalopathy. Brain Res. 2000; 858(2):227-36. DOI: 10.1016/s0006-8993(99)02309-4. View

Westphalen R, Scott H, Dodd P . Synaptic vesicle transport and synaptic membrane transporter sites in excitatory amino acid nerve terminals in Alzheimer disease. J Neural Transm (Vienna). 2003; 110(9):1013-27. DOI: 10.1007/s00702-003-0012-z. View

Baba A, Mitsumori K, Yamada M, Nishiyama N, Matsuki N, Ikegaya Y . Beta-amyloid prevents excitotoxicity via recruitment of glial glutamate transporters. Naunyn Schmiedebergs Arch Pharmacol. 2003; 368(3):234-8. DOI: 10.1007/s00210-003-0792-6. View

Lu W, Mi R, Tang H, Liu S, Fan M, Wang L . Over-expression of c-fos mRNA in the hippocampal neurons in Alzheimer's disease. Chin Med J (Engl). 1999; 111(1):35-7. View

Santpere G, Nieto M, Puig B, Ferrer I . Abnormal Sp1 transcription factor expression in Alzheimer disease and tauopathies. Neurosci Lett. 2005; 397(1-2):30-4. DOI: 10.1016/j.neulet.2005.11.062. View

Nielsen H, Minthon L, Londos E, Blennow K, Miranda E, Perez J . Plasma and CSF serpins in Alzheimer disease and dementia with Lewy bodies. Neurology. 2007; 69(16):1569-79. DOI: 10.1212/01.wnl.0000271077.82508.a0. View

Baker H, Frank O, Jaslow S . Oral versus intramuscular vitamin supplementation for hypovitaminosis in the elderly. J Am Geriatr Soc. 1980; 28(1):42-5. DOI: 10.1111/j.1532-5415.1980.tb00123.x. View

Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D . Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes. Proc Natl Acad Sci U S A. 2010; 107(15):7036-41. PMC: 2872449. DOI: 10.1073/pnas.1000645107. View

10.

Blass J, Gleason P, Brush D, Diponte P, Thaler H . Thiamine and Alzheimer's disease. A pilot study. Arch Neurol. 1988; 45(8):833-5. DOI: 10.1001/archneur.1988.00520320019008. View

11.

Squire L . The medial temporal lobe memory system. Science. 1991; 253(5026):1380-6. DOI: 10.1126/science.1896849. View

12.

Ke Z, Gibson G . Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism. Neurochem Int. 2004; 45(2-3):361-9. DOI: 10.1016/j.neuint.2003.09.008. View

13.

Calingasan N, Gandy S, Baker H, Sheu K, Kim K, Wisniewski H . Accumulation of amyloid precursor protein-like immunoreactivity in rat brain in response to thiamine deficiency. Brain Res. 1995; 677(1):50-60. DOI: 10.1016/0006-8993(95)00136-e. View

14.

Paoletti F, Mocali A, Tombaccini D . Cysteine proteinases are responsible for characteristic transketolase alterations in Alzheimer fibroblasts. J Cell Physiol. 1997; 172(1):63-8. DOI: 10.1002/(SICI)1097-4652(199707)172:1<63::AID-JCP7>3.0.CO;2-B. View

15.

Meador K, Loring D, Nichols M, Zamrini E, Rivner M, Posas H . Preliminary findings of high-dose thiamine in dementia of Alzheimer's type. J Geriatr Psychiatry Neurol. 1993; 6(4):222-9. DOI: 10.1177/089198879300600408. View

16.

Docagne F, Gabriel C, Lebeurrier N, Lesne S, Hommet Y, Plawinski L . Sp1 and Smad transcription factors co-operate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene transcription. Biochem J. 2004; 383(Pt 2):393-9. PMC: 1134081. DOI: 10.1042/BJ20040682. View

17.

Meador K, Nichols M, Franke P, Durkin M, Oberzan R, Moore E . Evidence for a central cholinergic effect of high-dose thiamine. Ann Neurol. 1993; 34(5):724-6. DOI: 10.1002/ana.410340516. View

18.

Infante J, Llorca J, Mateo I, Rodriguez-Rodriguez E, Sanchez-Quintana C, Sanchez-Juan P . Interaction between poly(ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer's disease risk. Dement Geriatr Cogn Disord. 2007; 23(4):215-8. DOI: 10.1159/000099471. View

19.

Muramatsu T, Kato M, Matsui T, Yoshimasu H, Yoshino A, Matsushita S . Apolipoprotein E epsilon 4 allele distribution in Wernicke-Korsakoff syndrome with or without global intellectual deficits. J Neural Transm (Vienna). 1997; 104(8-9):913-20. DOI: 10.1007/BF01285559. View

20.

Mandrekar-Colucci S, Landreth G . Microglia and inflammation in Alzheimer's disease. CNS Neurol Disord Drug Targets. 2010; 9(2):156-67. PMC: 3653290. DOI: 10.2174/187152710791012071. View