Shared Loci for Migraine and Epilepsy on Chromosomes 14q12-q23 and 12q24.2-q24.3

Overview

Journal Neurology

Specialty Neurology

Date 2012 Jan 6

PMID 22218271

Citations 7

Authors

A Polvi

A Siren

M Kallela

H Rantala

V Artto

E M Sobel

A Palotie

A-E Lehesjoki

M Wessman

Affiliations

Soon will be listed here.

Abstract

Objectives: To describe clinical characteristics and to identify susceptibility loci for epilepsy and migraine in a Finnish family with a complex phenotype.

Methods: Participating family members were interviewed and medical files were reviewed. The seizure classification was made according to International League Against Epilepsy criteria. Migraine diagnosis was made using the validated Finnish Migraine Specific Questionnaire for Family Studies and criteria according to the current International Classification of Headache Disorders-II. DNA samples were obtained from 56 family members and nonparametric genome-wide linkage analyses were performed using 382 polymorphic microsatellite markers. The most promising loci were fine-mapped with additional microsatellite markers.

Results: Clinical data were obtained from 60 family members of whom 12 (20%) had idiopathic epileptic seizures. Eight of those 12 (67%) also had migraine. Altogether 33 of the 60 family members (55%) had migraine. Significant evidence of linkage was found between a locus on 14q12-q23 and migraine (p = 0.0001). Suggestive evidence of linkage in this region was also found for epilepsy with generalized tonic-clonic seizures (p = 0.0034). In addition, significant evidence of linkage was found at a locus on 12q24.2-q24.3 (p < 0.001) for migraine alone and for the combined phenotype of migraine and epilepsy.

Conclusions: Our data suggest the occurrence of common susceptibility loci for epilepsy and migraine on chromosomes 14q12-q23 and 12q24.2-q24.3, implicating a shared genetic etiology for these 2 diseases.

Citing Articles

Migraine and Epilepsy in Children: A Narrative Review of Comorbidity and Similar Treatment Option.

Momen A, Jelodar G, Azizimalamiri R Iran J Child Neurol. 2024; 18(3):9-20.

PMID: 38988846 PMC: 11231672. DOI: 10.22037/ijcn.v18i3.44282.

A cross-sectional, multicenter survey of the prevalence and influencing factors for migraine in epilepsy.

Shi W, Sun H, Peng W, Chen Z, Wang Q, Lin W Epilepsia Open. 2024; 9(4):1406-1415.

PMID: 38808742 PMC: 11296102. DOI: 10.1002/epi4.12977.

A population-health approach to characterizing migraine by comorbidity: Results from the Mindfulness and Migraine Cohort Study.

Sudat S, Jacobson A, Avins A, Lipton R, Pressman A Cephalalgia. 2022; 42(11-12):1255-1264.

PMID: 35642092 PMC: 9872270. DOI: 10.1177/03331024221104180.

Migraine and epilepsy in the pediatric population.

Oakley C, Kossoff E Curr Pain Headache Rep. 2014; 18(3):402.

PMID: 24500640 DOI: 10.1007/s11916-013-0402-3.

Headache and epilepsy.

Bauer P, Carpay J, Terwindt G, Sander J, Thijs R, Haan J Curr Pain Headache Rep. 2013; 17(8):351.

PMID: 23801004 DOI: 10.1007/s11916-013-0351-x.

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