Intense CD44 Expression is a Negative Prognostic Factor in Tonsillar and Base of Tongue Cancer

Overview

Journal Anticancer Res

Specialty Oncology

Date 2012 Jan 4

PMID 22213301

Citations 24

Authors

David Lindquist

Andreas Ahrlund-Richter

Miklos Tarjan

Tibor Tot

Tina Dalianis

Affiliations

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Abstract

Background: Patients with tonsillar and base of tongue cancer, which are human papillomavirus (HPV) positive, have a better clinical outcome than those with HPV-negative tumors. The identification of additional predictive markers for response to therapy could still be of great use.

Materials And Methods: Tumor markers CD44, p16, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), E-cadherin, cyclooxygenase-2 (COX 2), Ki-67, and p27 were analyzed by immunochemistry, and HPV status was tested by polymerase chain reaction (PCR) in tumors from 73 patients and correlated to survival.

Results: High intensity CD44 staining (p=0.006) and high EGFR expression (p=0.026) were indicators of poor prognosis, while high p16 expression (p=0.021) and younger age (p=0.002) were positive prognostic markers for disease-specific survival. Furthermore, staining of CD44 (p=0.026) and age (p=0.002) were shown to be strong prognostic markers in multivariate analysis, which should be evaluated further for possible use in clinical practice.

Citing Articles

CD44, PDL1, and ATG7 Expression in Laryngeal Squamous Cell Carcinomas with Tissue Microarray (TMA) Technique: Evaluation of the Potential Prognostic and Predictive Roles.

Puzzo L, Bianco M, Salvatorelli L, Tinnirello G, Occhiuzzi F, Latella D Cancers (Basel). 2023; 15(9).

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Whole-Exome Sequencing of HPV Positive Tonsillar and Base of Tongue Squamous Cell Carcinomas Reveals a Global Mutational Pattern along with Relapse-Specific Somatic Variants.

Ahrlund-Richter A, Holzhauser S, Dalianis T, Nasman A, Mints M Cancers (Basel). 2022; 14(1).

PMID: 35008243 PMC: 8750256. DOI: 10.3390/cancers14010077.

Prognostic Markers and Driver Genes and Options for Targeted Therapy in Human-Papillomavirus-Positive Tonsillar and Base-of-Tongue Squamous Cell Carcinoma.

Nasman A, Holzhauser S, Kostopoulou O, Zupancic M, Ahrlund-Richter A, Du J Viruses. 2021; 13(5).

PMID: 34069114 PMC: 8156012. DOI: 10.3390/v13050910.

Targeted Therapy With PI3K and FGFR Inhibitors on Human Papillomavirus Positive and Negative Tonsillar and Base of Tongue Cancer Lines With and Without Corresponding Mutations.

Holzhauser S, Wild N, Zupancic M, Ursu R, Bersani C, Nasman A Front Oncol. 2021; 11:640490.

PMID: 34046344 PMC: 8144504. DOI: 10.3389/fonc.2021.640490.

EGFR Protein Expression Relates with Tumor Histology, Methylation Status of EGFR and HPV16 E6 Viral Load in Oropharyngeal Carcinoma.

Suzuki Y, Fukumura Y, Asahina M, Fujimaki M, Ohba S, Matsumoto F Head Neck Pathol. 2021; 15(3):743-756.

PMID: 33428063 PMC: 8385027. DOI: 10.1007/s12105-020-01261-w.